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iScience: Yong Chen's team reveals the molecular mechanism by which DPY30 promotes methyltransferase activity in the MLL complex

 Last Update: 2022-09-20
 Source: Internet
 Author: User

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H3K4 methylation modification plays a key role in enhancer activity regulation, transcriptional activation, and cell fate decisions, and its abnormalities can lead to the occurrence of a variety of leukemias and malignant tumors

Recently, the Chen Yong Research Group of the Center for Excellence in Molecular and Cell Science (Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences published in the journal iScience entitled: DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different Substrates' research paper reveals the molecular mechanism

In this study, the team found that DPY30 can enhance the activity

The research team then elucidated the methyltransferase activity

Molecular mechanism of DPY30 promoting methyltransferase activity of MLL complexes

DPY30 is highly expressed in a variety of cancers, and previous studies have shown that the pro-cancer effects of DPY30 are associated

Zhao Lijie, a doctoral student at the Center for Molecular Cell Excellence of the Chinese Academy of Sciences, is the first author of the paper, and researcher Chen Yong is the corresponding author

Original source:

Lijie Zhao， et al.

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