iScience: Fat cells play a central role in cognitive decline and neurodegenerative diseases

Neurons express receptors for various adipokines, suggesting that the factors released by adipose tissue may communicate directly with the brain

The Na and K-ATPase signaling pathways in adipocytes are involved in the pathogenesis of various metabolic diseases, and systemic administration of NaKtide can effectively reduce oxidative stress, inflammation and degenerative phenotypes

Recently, Marshall University researchers published in Cell, sub-titled TV iScience: Role of adipocyte Na, K-ATPase Oxidant Amplification Loop in Cognitive Decline and Neurodegeneration research papers

The study showed that fat cells control the systemic response to brain function, leading to impaired memory and cognitive abilities in mice

Targeting adipocytes against Na, K-ATPase may improve these results.

First, the research team constructed transgenic mice that express NaKtide in a tetracycline (TET) dependent manner (TET-On) under the control of the adiponectin promoter

By measuring the concentration of NaKtide by ELISA, the research team further confirmed the presence of doxycycline-induced NaKtide expression in visceral adipose tissue

Next, the research team evaluated the learning and memory abilities of the mice through several cognitive tests

Finally, in order to study the impact of Western->

In summary, this work found that the overexpression of adipocyte-specific NaKtide peptides in the mouse model improved insulin resistance, inflammation, and neurodegenerative phenotypes, confirming that the Na and K-ATPase signaling pathways of adipocytes can induce the hippocampus of the brain.

Sodhi, K.