Is the effect of resveratrol on heart health clear?

Resveratrol, a compound found in red wine, can affect blood pressure and the function of fat cells, according to a study that could help explain the effects of resveratrol on heart health Red wine appears to have a direct effect on blood pressure, but resveratrol can also affect the function of fat cells and reduce the risk of developing obesity, according to two studies published in the American Journal of clinical nutrition This research result is very concerned by evi mercken and Rafael de cabo from the International Institute of aging In the comments after AJCN, scientists from the National Institutes of Health pointed out that the potential therapeutic effect of resveratrol in preventive medicine and metabolic diseases cannot be ignored They asked carefully designed human experiments to further explore the potential role of red wine and resveratrol The promise of longevity resveratrol, a powerful polyphenol and antifungal chemical, is often touted as a biologically active substance in grapes and red wine, and has to do with the so-called "French paradox" This sentence was created by Dr Serge Renaud from Bordeaux law in France Although France has a relatively high fat diet and high alcohol consumption, their incidence of heart disease and obesity is very low In 2003, when David Sinclair and his team from Harvard University reported that resveratrol can prolong life, there was a lot of interest in resveratrol The research, published in nature, has been greatly praised by the international media and ignited the flame of an anti-aging drug Resveratrol and obesity in the first study, researchers from the Israel Institute of technology pointed out in the first study that red wine can improve heart health by affecting gene signals from cells in blood vessels that have a role in heart health function The second study was also published in the American Journal of clinical nutrition Scientists from the University of Ulm in Germany pointed out that resveratrol has a direct impact on fat masses and tissues A cell study using resveratrol found that they mainly act on the SIRT1 gene The data showed that the fat in the cells was inhibited by resveratrol exposure The researchers pointed out that our study opened a new perspective, resveratrol induced intracellular signaling pathway can be used to prevent and treat the adverse effects of obesity related endocrine and metabolism Independent commentators mercken and de cabo point out that both studies have shown that resveratrol has potential fundamental benefits in metabolic disorders Both mercken and de cabo pointed out in the American Journal of clinical nutrition that the above two studies clearly show that resveratrol has a direct or indirect effect on the prevention of cardiovascular disease But they still have some questions: 1) is resveratrol really a direct effect or is it similar to an endogenous signal molecule? 2) Do resveratrol's metabolic bioactive molecules have their own rights?