Inventory: Those human cell maps constructed in 2021

The Human Cell Atlas is planned to be launched in 2017 and is dedicated to drawing a reference map of all cells in the human body, including cell types, numbers, locations, relationships, and molecular composition

In the past four years, through the efforts of many laboratories around the world, the Human Cell Atlas Project has published a number of important results

1.

Title: Developmental cell programs are co-opted in inflammatory skin disease

Researchers in the United Kingdom, Israel, and the United States used developing fetal skin, healthy adult skin, and skin samples from patients with skin diseases as research objects.

2.

Title: Spatiotemporal analysis of human intestinal development at single-cell resolution

Researchers at the University of Oxford in the United Kingdom used single-cell RNA sequencing and spatial transcriptomics to construct a large-scale single-cell spatiotemporal map of human intestinal development, mapping morphogenesis across time, locations, and cell compartments

3.

Title: Cells of the human intestinal tract mapped across space and time

Focus on the gut again! This large-scale study has drawn a map of human intestinal cells from early development to adulthood, creating the most comprehensive map of intestinal cells to date

4.

Title: A multimodal cell census and atlas of the mammalian primary motor cortex and other

The Brain Cell Census Network (BICCN) project of the BRAIN Project has recently reached its first important milestone, revealing the cell type map of the primary motor cortex of mammals

5.

Title: Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

Researchers from the Memorial Sloan Kettering Cancer Center in the United States have collaborated to reveal the characteristics of plasticity, metastasis, and immunosuppression in the human small cell lung cancer map
.
To determine the heterogeneity of different subtypes of tumors and their associated microenvironment, the researchers sequenced 155,098 transcriptomes from 21 human biological samples, including 54,523 small cell lung cancer (SCLC) transcriptomes
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They observed that the tumor diversity of SCLC is greater than that of lung adenocarcinoma, driven by typical, intermediate, and mixed subtypes
.
Learn more>>

6.
Melanocyte Atlas

Title: Human melanocyte development and melanoma dedifferentiation at single-cell resolution
Publication: "Nature Cell Biology"

Researchers at the Huntsman Cancer Institute (HCI) at the University of Utah created the first human melanocyte map
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When further analyzing the atlas data, the researchers found different types of melanocytes, including the origin cells of acral melanoma, which is a subtype of melanoma that mainly affects people of color
.
They predict that these findings will lead to more targeted treatments for melanoma
.
Learn more>>

7.
Oral Mucosal Cell Atlas

Title: Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity
Publication: "Cell"

Researchers from the National Institutes of Health have mapped the single-cell transcriptome of the oral mucosa of healthy individuals and patients with periodontitis
.
The researchers revealed the complex cell atlas of oral mucosa tissue and identified epithelial and stromal cell populations with inflammatory features such as promoting antibacterial defense and neutrophil recruitment
.
This work helps characterize the role of tissue matrix in regulating mucosal tissue homeostasis and disease pathogenesis
.

8.
Single-cell atlas of teeth

Title: A single-cell atlas of human teeth
Publication: "iScience"

Researchers from the University of Zurich in Switzerland have drawn the first single-cell map of a human tooth
.
They conducted an in-depth analysis of the stem cell population of the tooth and its microenvironment, and found that there is great cellular heterogeneity in the dental pulp and periodontal tissue
.
This research highlights the complexity of tooth tissue and helps people better understand the cellular and molecular properties of human tooth tissue
.
Learn more>>

9.
Single cell atlas of the eye

Title: Multi-species single-cell transcriptomic analysis of ocular compartment regulons
Publication: "Nature Communications"

Scientists in Singapore have constructed the world's first single-cell map of human and pig eyes
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This allows them to create disease maps of genes related to eye diseases through different cell types, as well as key switches that control the specialization of individual eye tissue cells
.
This work will help provide new insights into human eye diseases and age-related eye diseases, and may pave the way for regenerative medicine and cell replacement therapy for eye diseases
.
Learn more>>

10.
Cellular map of cerebellar development

Title: Spatial and cell type transcriptional landscape of human cerebellar development
Publication: "Nature Neuroscience"

Researchers from Seattle Children's Research Institute and other institutions have systematically mapped the molecular, cellular, and spatial composition of the human fetal cerebellum by combining laser capture microscopy and SPLiT-seq single-cell nuclear transcriptomics analysis
.
They analyzed different functional regions and gene expression dynamics within cell types and throughout development
.
These data provide resources for exploring the cellular basis of human cerebellar development and diseases
.