Inventory: summary of listed "TiNi" drug information

As for Tinian drugs, some people said a few years ago that "it's almost over" and "it's broken", and many people are extremely dissatisfied with its research and development, that is, the so-called "waste of scientific research".. But what's the truth? As a matter of fact, up to now, there are dozens of drugs on the market, dozens of NDA, and more than 20 clinical phase III drugs.. So it proves that people are still very keen on it More needless to say, the marketing of this kind of drugs does not bring a little bit of good news to patients Many drugs significantly extend the life span of different stages and types of cancer patients, and improve the quality of life There is no doubt that its milestone status In my opinion, more importantly, the successful experience of TiNi drugs is worth learning and thinking If it can be applied to other areas of drug research and development that need to be solved, it will be more perfect The incidence rate of cancer is still grim In February 2018, the National Cancer Center released the latest issue of the national cancer statistics It is estimated that in 2014, there were 3.8 million new cases of malignant tumors in China (2.11 million men and 1.69 million women), which is equivalent to that more than 10000 people were diagnosed with cancer every day, that is, 7 people were diagnosed with cancer every minute Among them, the incidence rate of nausea and cancer was lower in people under 30 years old, and the incidence rate increased rapidly after 30 years old The peak rate reached 80 years old and then began to decline According to the number of cases, lung cancer still ranks first in the country, with an annual incidence of about 780000, followed by gastric cancer, colorectal cancer, liver cancer and breast cancer Lung cancer and breast cancer ranked first in male and female sex Figure 1 the incidence rate of the first 5 cancer "Nei drugs" from the hot to the mature in the national incidence rate has never ceased in the process of finding anticancer drugs Various countries and regions have also organized many large-scale scientific research inputs according to their own strength, such as the early American "Declaration of war against cancer" and the "anticancer moon landing plan" in recent years Although cancer has not been completely conquered, many kinds of drugs have been found, and they have been widely used in clinical practice, significantly prolonging the survival period of patients, improving the quality of life of patients, and even being completely "cured" In this process, Tinian drugs have played an important role The first TiNi drug on the market is imatinib-gleevec, which is used to treat the late Philadelphia chromosome positive chronic myelogenous leukemia, the late or metastatic gastrointestinal stromal cell tumor, the Ph chromosome positive acute lymphocytic leukemia and so on Its listing has opened the tide of the large-scale development of TiNi drugs and opened the small molecule tyrosine stimulation Enzyme inhibitors are the prelude to cancer resistance, the absolute milestone drug! Subsequently, gefitinib, erlotinib, dasatinib, sunitinib and other drugs have been listed, which has become a solid cornerstone of Tinian drugs Up to now, imatinib, erlotinib, dasatinib, nilotinib, sunitinib, and irutinib are still the varieties with an annual sales volume of more than 1 billion US dollars (imatinib reached nearly 5 billion US dollars in 2014); and the rapid development of domestic tinib drugs, exetinib and apatinib, is even more expected Information list of TiNi listed drugs Through database query, there are 31 drugs with tinib in the names of listed drugs, which have been on the market since 2001 The indications mainly focus on tumors, followed by skin diseases, blood system diseases, immune system diseases, musculoskeletal and connective tissue diseases The targets are almost all hot research targets The R & D companies are also focused on large-scale ones Pharmaceutical companies See Table 1 for details The target list and target research of TiNi drugs have always been the top priority of drug research and development The important targets and channels of TiNi drugs are complex and systematic Therefore, for the corresponding targets of listed drugs, search for relevant information, as shown in Table 2 The structure of Tinian drugs on the market summarizes the 31 Tinian drugs on the market, from imatinib mesylate in 2001 to fostamatinib disodium hexahydrate in 2018, all of which are small molecule chemical drugs, which are worth systematic review and deliberation See Figure 2 for the chemical structure Figure 2 From 2000 to now, the chemical structure of TiNi drugs on the market has been felt Firstly, the above information is summarized as self-learning Secondly, let's talk about our feelings.. Thank you for Tinian drugs! A family member of the author once suffered from non-small cell lung cancer It was found to be in the late stage It was about 2012 After chemotherapy, gefitinib was used continuously for many years The effect was really good Although it was regrettable that the drug resistance finally came into being, the disease developed further and died in March this year But it is undeniable that through the use of gefitinib, its survival time has been greatly extended, so that children can be as filial as possible in a limited time Objectively speaking, it is more gratifying However, the time axis of anti-cancer still needs us to make more efforts to shorten it After all, life is limited Only when cancer is conquered at an early date or becomes a chronic disease completely, can we retain the most important and irreplaceable "feeling" in our life as much as possible Reference: drug data National Cancer Center: the latest national cancer report in 2018 imatinib: landmark anti-cancer drugs of blockbuster drugs