Inventory: A selection of Lancet studies on September 26, 2020.

1. Successful DOI of the Russian New Coronary Pneumonia Vaccine Phase I-II Study: https://doi.org/10.1016/S0140-6736 (20)31866-3 Researchers from Russia have successfully developed two COVID-19 vaccines. One is the recombinated adenovirus type 26 (rAd26) vector vaccine, and the other is the recombinated adenovirus type 5 (rAd5) vector vaccine, both of which carry the peak glycoprotein (rAd26-S and rAd5-S) genes of SARS-CoV-2.
recently, researchers evaluated the safety and immunogenicity of the two vaccines.
76 volunteers participated in the study.
study found that both vaccine preparations are safe and well-to-do.
most common adverse reactions were pain at the injection site (58%), high fever (50%), headache (42%), fatigue (28%) and muscle and joint pain (24%).
most adverse events are mild and no serious adverse events are found.
all participants were vaccinated and produced anti-SARS-CoV-2 glycoprotein antibodies.
On the 42nd day, the frozen vaccine preparation binding domain-specific IgG antibody titration was 14703, the freeze-dried vaccine preparation was 11143, the neutral antibody frozen vaccine preparation was 49.25, the freeze-dried vaccine preparation was 45.95, and the serum conversion rate was 100%.
On the 28th day, cell-mediated reactions were detected in all participants, with the median cell proliferation of frozen vaccine preparations at 2.5% CD4 plus and 1.3% CD8 plus, and the median cell proliferation rate of freeze-dried preparations at 1.3% CD4 plus and 1.1% CD8 plus.
2. DoI for the treatment of chronic pelvic pain: https://doi.org/10.1016/S0140-6736 (20)31693-7 Global 2-24% of women are affected by chronic pelvic pain, and there is no effective treatment.
Gabba spray has good therapeutic effect on some chronic pain.
recently assessed the efficacy and safety of gabal spray for patients with chronic pelvic pain without significant pelvic lesions.
306 patients were involved in the study, including 153 in the Gabba spray group and 153 in the placebo group.
13-16 weeks, there was no significant difference in the highest average pain scores between the groups.
NRS pain score was 7.1 in the Gabba spray group and 7.4 in the placebo group.
the Gabba spray group was -1.4 on average and -1.2 on the placebo group compared to the baseline.
average NRS pain score was 4.3 in the Gabba spray group and 4.5 in the placebo group, with average changes of -1.1 and -0.9 compared to the baseline, respectively.
high proportion (7 vs 2%) of serious adverse events occurred in the Gabba spray group, with the most common adverse events being dizziness, drowsiness and visual impairment.
. A growing body of evidence from the Global Vaccination Importance, Safety or Effectiveness (Vaccine Confidence) Cognitive Change Study DOI: https://doi.org/10.1016/S0140-6736 (20) 31558-0 shows that delays or denial of vaccinations occur frequently due to a lack of trust in the importance, safety or effectiveness of vaccinations, as well as ongoing access issues.
although immunization coverage has been reported worldwide, data on vaccination confidence are currently lacking.
researchers recently surveyed vaccination confidence in 149 countries between 2015 and 2019.
found that confidence in the importance, safety and effectiveness of vaccines declined among people in Afghanistan, Indonesia, Pakistan, the Philippines and South Korea in 2015-19.
six countries, including Afghanistan, Azerbaijan, Indonesia, Nigeria, Pakistan and Serbia, there has been a significant increase in the proportion of respondents who strongly question vaccine safety.
there are signs that vaccination confidence in some EU member states, including Finland, France, Ireland and Italy, has improved between 2018 and 2019, but in Poland it continues to decline.
importance of vaccines, rather than their safety or effectiveness, is the most important factor affecting vaccination compared to other determining factors.
religious beliefs are important human factors affecting vaccination, and vaccination rates for religious minorities tend to be low.
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