Intestinal research is helping us fight obesity!

, June 24, 2020 /
PRNewswire/ -- By delving into metabolis
m, researchers at Flinders University have found that the ability to sense the nutrients of intestinal chromium (EC) cells (along the intestinal arrangement, almost all of the serotonin in the body) in mice with foodborne obesity and metabolic diseases by a high-fat diet has changedDr, DrAlyce Martin, is a member of a research team led by Damien Keating of Flinders University, and the findings have been published recently in the journal Eurovision and MotilityDrMartin said: "Our recently published research builds on laboratory research published during my PhD years, which showed that EC cells that produce serotonin in the gut play an important role in the sensory cells in their environmentThis is also based on our study of the human body, which showed an increase in the number of circulating serotonin and duodenal EC cells in obese people"
photo source:Neurogastroenterology and Motility
Although the metabolic effects of intestinal-derived serotonin are known, the underlying causes of the increase in serotoninobesity anddiabetes remain unclear.", however, Dr Martin said the new study provides new insights into the mechanisms by which EC cells functionChanges in the function of EC cells can lead to changes in circulating serotonin, which can be seen in obesity and metabolic diseases
as well as related gastrointestinal diseases, including gastric palsy and nausea "We've shown that these cells have the ability to sense and release serotonin and choose nutrients in healthy conditions, depending on where they are in the gut," Dr Martin said "Now we've shown that in obesity
diabetes models, these cells' perception of nutrients, as well as the number of cells, are affected by diet." a study by Alyce Martin, Lauren Jones, Claire Jessup, Emily Sun and Damien Keatp - Diet differentially regulates enterochromaffin cell serotonin, content density and nutrient sy'n the mouse and small small large - has been published in Wiley's magazine a major study published in the Proceedings of the National Academy of Sciences in 2019 by researchers at Flinders University, which also laid the groundwork for the new paper The study showed that even under healthy conditions, gut bacteria communicate with EC cells, which affects metabolism This is the first evidence to highlight that intestinal-derived serotonin is the of bacteria affecting metabolism Photo Source: PNAS intestinally derived serotonin activity in these metabolic processes is directly related to metabolic disorders such as obesity and type 2 diabetes university researchers at Flinders University are now looking at how serotonin in EC cells affects intestinal dynamics -- and how these EC cells respond to mechanical stimuli and how they communicate with intestinal neurons that are part of the intestinal brain axis Dr Martin said: "We are making several progress escticions to understand the dynamic relationship between the EC cells that produce serotonin and their intestinal environment, which ultimately affects physiological processes such as intestinal function and metabolism " (BioValleyBioon.com) References: Gut Research delves deeper into the Alyce M Martin et al, Dieti challi regulates enterochromaffin cellerotonin content, density yslingy in the mouse
small small small DOI: 10.1111/nmo.13869
Alyce M Martin et al.
Keating The gut microbiome regulates shost glucose homeostasis is via serotonin PNAS October 1, 2019 116 (40) 19802-19804; first publicly published September 16, 2019 doi.org/10.1073/pnas.1909311116
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