Interpretation! How can scientists improve survival rates in cervical cancer patients by targeting "zombie" cells that act on aging?

December 21, 2020 // -- In a recent study published in the international journal Cancers entitled "Senescence-Associated Secretory Phenotype Survival and Therapeutic Therapeutics in Cervical Cancer," scientists from institutions such as the University of Augusta's Georgia School of Medicine found that targeting aging "zombie" cells could improve survival rates in patients with cervical cancer.
that cervical cancer patients' response to therapy is closely related to survival and levels of 10 proteins in the blood, which are associated with the state of aging cells. In the
study, researchers analyzed the pretreatment levels of these proteins in the bodies of 565 Peruvian cervical cancer women who received near-distance radiation therapy (standard endotherapy), external radiation therapy, and phases 2 and 3 of both therapies, and found that women with lower levels of protein secreted by senescing cells had higher survival rates than women with higher levels of aging cell-related secretion esopiographs (SASPs).
addition, near-range radiation therapy can implant radiation sources near a woman's cervix, which greatly improves the survival rate of patients with higher SASPs levels in the body, but has little effect on patients with lower levels.
-related findings suggest that cell aging may be a factor in survival and therapeutic response in cervical cancer patients, and suggest that aging reduction therapy may be an effective strategy to improve the prognostic prognosticity of treatment in cervical cancer patients.
'We wanted to figure out how to better treat cervical cancer, and what factors play a key role in determining which patients survive and how they respond to radiotherapy,' said Dr. Jin-Xiong She, a researcher at Haymanj/public domain.
researchers want to improve treatments for cervical cancer patients by managing aging.
In women with moderate to high levels of SASPs in the blood, using a class of drugs called senolytics, which can be used as an ad-help therapy, senolytics can target the elimination of senolytics and improve the occurrence of age-related problems and diseases.
cervical cancer is one of the most common gynaecological cancers and is almost entirely caused by the human papillomavirus (HPV).
although routine cervical smears are largely available to diagnose pre-cancer changes, or to prevent HPV infections by vaccination.
fact, with the exception of cervical and endometrial cancers, survival rates for the most common cancers have improved significantly since mid-1970, according to the American Cancer Society.
researchers want to change that through research, and preliminary research evidence suggests that targeted aging may be an effective tool. In the
study, researchers analyzed the levels of a total of 19 blood proteins and found that cells secreted them in pathological conditions such as precancerotes or cancerous cervixes, although they were unable to restore why they were produced, and that special liquid biopsies could routinely monitor them regularly.
researchers found that the levels of 10 of these proteins, which are directly related to cell aging, were directly related to cervical cancer patients with an average age of 49, whether as important destructive and inflammatory SASPs or as proteins involved in regulating SASPs.
Although cancer cells are often directly associated with rapid growth that promotes cancer growth, aging cells cannot divide and multiply, so researchers classify the amount of protein secreted by these aging cancer cells as "bad things" that can help produce an inflammatory state in which the cancer survives and help create a basis for the spread of cancer, while also protecting cancer cells from the effects of radiation therapy.
these aging proteins can really change the way cancer cells respond to therapy.
researchers then used machine learning techniques to reveal a link between high levels of SASP and lower survival rates in patients.
of the patients included in the study, each stage 2 cancer patient and most stage 3 cancer patients received internal and external radiation therapy, and 86 stage 3 patients received only external radiation therapy.
later in the year, researchers needed further research to clarify whether patients with low levels of SASP or benefited from brachytherapy, but they do not appear to have found the benefits of this proximity therapy for patients with cervical cancer.
() References: Sharad Purohit, Wenbo Zhi, Daron G. Ferris, et al. Senescence-Associated Secretory Phenotype Determines Survival and Therapeutic Response in Cervical Cancer, Cancers (2020). DOI:10.3390/cancers12102899。