Intermittent break-ups that make you "see" more clearly?

Introduction:occasionally hungry not only can lose weight, but also diabetic people a pair of bright eyes? Intermittent break-ups have been found to prevent diabetic retinal lesions, the key of which lies in the !!! You're right, right, gut bacteria! Here's what's in
>>>Article Outline Septh point
01: Intermittent break-up of food and the link between intestinal bacteria in diabetes Septic point
02: How can improvements in gut bacteria prevent diabetic retinal lesions?Research HighlightsExtreme View PointAbstractAn experimental study in diabetes-based mice published in the journal
Diabetes showed that seven months of intermittent break-up can recombine the gut bacterium and raise levels of the neuroprotective agent TUDCA to prevent diabetic retinopathy. At the same time, intermittent cut-off can activate TUDCA's subject TGR-5 to prevent further development of retinal lesions.Point 01The link between intermittent break-up of food and intestinal bacteri groups in diabetes intermittent break-up and intestinal bacteria regulation intermittent cut-off (
Intermittent Fasting), as the name suggests, is the voluntary non-intake of food for a period of time. The "extreme vision" has made a comprehensive interpretation of this method of cut-off>>>intermittent cut-off can be regulated by: bio-clock intestinal bacteria improved lifestylethese three aspects have a positive impact on our health
intestinal bacteria are key factors in regulating the body's metabolism, and their composition is importantly affected by eating signals. Intermittent break-up can regulate the rhythm of the gastrointestinal tract by altering the composition of the intestinal bacteria, directly affecting the biological rhythm of the intestinal bacteria and regulating their metabolic function. Simply put, intermittent break-up can be achieved by regulating the gut bacteria, so that our gastrointestinal tract is doing the right thing at the right time
- intermittent break-off can also change the adipose tissue by changing the gut bacteria, promote the body to produce more beneficial fat, so as to achieve weight loss, fat reduction and liver care effect
changes in the gut bacteria of diabetic mice caused by intermittent break-ups?the above-mentioned experiments in healthy people or animals, but what if the subjects or the animals themselves have a chronic disease? In the latest study, which focuses on this paper, the researchers conducted a comparative experiment in two groups of diabetic mice, one of which was intermittently fed every
24 hours and the other at any time. After seven months, diabetic mice with intermittent cut-off feeding were found to have higher survival rates than the control group and had fewer retinal lesions.the reason, intermittent break-ups altered the intestinal bacillus structure in mice, increasing the levels of
Firmicutes while reducing the levels of Bacteroides and Verrucomicrobia. Changes in the structure of the intestinal bacteri group resulted in an increase in gut mucin, goblet cell number, and velvet length in mice that were fed intermittently, as well as a decrease in the level of plasma peptide polysaccharides.point of view
02 How can the improvement of intestinal bacteria prevent diabetic retinal lesions
?causes and consequences of diabetic retinal lesions Diabetic retinal lesions are simple and are a type of eye capillaries lesions caused by diabetes
Its culprit is the body's high blood sugar levels, over time, elevated blood sugar will weaken and damage the retina microvascular, may lead to retinal bleeding, overflow and even swelling. Don't look down on diabetic retinal lesions, as there are now more than 93 million patients worldwide! And if not treated properly, the most serious can lead directly to blindness. we just said that in the latest study, intermittent break-ups were found to regulate the intestinal bacteria in mice, thereby improving diabetic retinal lesions. But what mechanisms do gut bacteria use to improve diabetic retinal lesions? the association between improved intestinal bacteria and retinal lesions Further studies have shown that intermittent break-ups can protect the retina in at least two ways: 1.
changes in the abundance of the microbiota promote the increase of secondary bile acid ❖ intermittent break-up of food increased the content of thick-walled bacillus, while reducing the content of Bacillus anthroposis and wart microbacteria; ❖ Changes in this bacterium further affect the activity of two enzymes (7 alpha-HSDH and 7 beta-HSDH, hydroxysteroid dehydrogenase), which converts a substance called taurine goose deoxycholic acid TCDCA (primary bile acid) into taurine bear deoxycholic acid TUDCA (secondary bile acid). ❖ TUDCA is a neuropulant that protects the retina of mice when combined with its subject TGR-5, which is found in nerve cells of retinal primary nerve cells. 2.
secondary bile acid subject activation, further protection of the retina ❖ intermittent breakage can further activate TGR-5, lower its key downstream target tumor necrosis factor α (TNF alpha, involving systemic inflammation of cytokines), to prevent the further development of retinal lesions. The detailed principle is shown in the figure below. ❖ the use of drugs to activate TGR-5, the same preventive effects can be achieved, further demonstrating the activation effect of intermittent break-up on TGR-5. detailed principles are shown in the following illustration
>>> Smopt
>>> has two types of bile acid in the liver: primary bile acid (
primary bile acid) and secondary bile acid. Cholesterol can be synthesized into primary bile acid, which is converted into secondary bile acid under the role of enzymes. The study Liang o'clock this study found another effect of intermittent breakage, which is to prevent diabetic retinal lesions by changing the environment of the intestinal bacteria, which is important for the clinical application of intermittent cut-off. Another bright spot in this study is the discovery of the positive effects of
TGR-5 on the retina, so TGR-5 may be a new target for treating retinal lesions in the future. of course, since the study was based on a group of diabetic mice, its conclusions have limitations, and if they are pushed to the human level, clinical trials are required. However, intermittent break-up shows to some extent its recombinant effect on the intestinal bacteriogroup, which provides a new direction and important reference value for future research on the prevention and treatment of complications of metabolic diseases, such as eye diseases. In addition, neurological diseases have long been a major problem in the prevention and treatment of chronic diseases, and this study shows the potential for intermittent break-ups that can regulate nervous system function by altering the intestinal bacteria, potentially bringing new ideas to degenerative neurological diseases such as Alzheimer's and Parkinson's disease. Let's look forward to more important breakthroughs in intermittent break-ups in the future! References Eleni B, Yuanqing Y, Leni M, Cristiano P, V, Ruli G, Yaqian D et al. Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice. American Diabetes Association, 2018, db180158 [2] Patterson R E and Sears D D. Metabolic Effects of Intermittent Fasting. Annual Review of Nutrition, 2017, 37: 371-393 [3] Ryan L, Tien Y W and Charumathi S. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond), 2015, 2:17 [4] Eye problems and diabetes introduction. MedicineNet.com, 2016 [5] Diabetic retinopathy. Diabetes.co.uk, 2018