Interaction between Angelica dahurica and chemicals
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Last Update: 2020-04-03
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Source: Internet
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Author: User
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2015-12-07 classification: efficacy 0 people commented on Angelica dahurica root as a drug, and its extract has anti-inflammatory, analgesic and antipyretic effects The main active components of Angelica dahurica are furacoumarin, coumarin and scopolamine When Angelica dahurica extract was injected intravenously to rats, the Cmax of diazepam increased 4 times, while AUC and clearance rate and other pharmacokinetic parameters did not change significantly Intravenous injection of Angelica dahurica extract can prolong the half-life of tolbutamide and reduce its clearance rate, which may be due to the inhibition of CYP2E1 and the reduction of liver intrinsic clearance rate In vivo and in vitro studies have shown that Angelica dahurica extract and its furunculocoumarins can inhibit a wide range of CYP isoenzymes, including cyp2e and CYP3A.
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