Inter J Cancer: Self-binding! Trigger melanoma suicide switch to fight cancer!

April 20, 2020 /
BIOON/ -- Scientists at the Centennial Institute in Sydney, Australia, have reported a new strategy to fight melanoma melanoma is the most dangerous form of skin cancer, killing about 1700 people in Australia each year researchers used drugs to suppress two different proteins and found that they could effectively kill melanoma by inducing apoptosis , a process of cell self-destruction that occurs when cells no longer need them this new treatment strategy has the potential to benefit a group of melanoma patients who do not respond to targeted or immunotherapy image source: Dr Hin-Yi Teng, lead author of the study
cc BY-SA 3.0 and a researcher at the 100-year-old Research Institute
's of Oncology and for Melanoma and Immunology, said: "It is extremely difficult to induce apoptosis because high levels of antiapopin or 'protected' protein are found in cancer cells melanoma." These protective proteins help melanoma cells survive, grow, and in some cases help resist advanced drug treatments in this study, the researchers jointly inhibited the protein MCL1 and proteins from the bromine and outer end (BET) family Both substances are thought to play a key role in protecting and supporting melanoma cancer cells in the body Dr said: "Our study shows that the combination of BET and MCL1 inhibitors is very effective in killing melanoma The protective capacity of the BET and MCL1 proteins declines under the action of drug inhibitors and causes cancer cells to self-destruct co-author of the study, Dr Jeamy Tiffen, is also a member of the project in the Oncology and Immunology of melanoma at the 100-year
-old institute She said the team's research is significant and offers a potential new treatment strategy for patients melanoma as many as half of melanoma patients do not respond to immunotherapy, and most tend to develop acquired resistance to targeted therapy Our study examined a large number of human melanoma cell lines and mouse models We see a significant reduction in the of melanoma in both cases, which bodes well for the next phase of development," Dr Tiffen said study was published in The International Journal of Cancer Melanoma is the most common cancer among young Australians, ranging in age from 15 to 39 (BioValleyBioon.com) Reference: Triggering melanoma cell death to fight cancer with it 'uicide witch' Hin-Yi Teng et al.
Co-targeting BET protein and MCL1 induce ynergitic cell death in melanoma, International Journal of Cancer (2020) DOI: 10.1002/ijc.33000