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Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide, with a five-year survival rate of no more than 10%.
Pancreatic Cancer Management
In this case, it is particularly necessary to be able to predict overall survival (OS), identify biomarkers that require enhanced induction regimens and patients who benefit from radiotherapy and chemotherapy .
In this case, it is particularly necessary to be able to predict overall survival (OS), identify biomarkers that require enhanced induction regimens and patients who benefit from radiotherapy and chemotherapy.
Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys baseline neutrophil count can predict the OS of LAPC patients
An international multicenter randomized phase 3 trial (LAP07) enrolled 442 patients with LAPC.
Prognosis of patients with or without neutropenia at baseline
Prognosis of patients with or without neutropenia at baselineAmong 442 patients, 47 (11%) patients with neutrophilia had poorer OS (median 8.
The OS of 47 patients (11%) with neutrophilia was poor.
Cumulative recurrence rate of patients with or without systemic inflammation (SI) treated with CT or RCT
Cumulative recurrence rate of patients with or without systemic inflammation (SI) treated with CT or RCTIn addition, the increase in neutrophil count also indicates that the efficacy of radiotherapy and chemotherapy for local control will be reduced .
Elevated neutrophil count also indicates a decrease in the efficacy of radiotherapy and chemotherapy for local control
In summary, the study shows that in LAPC patients, baseline neutropenia and absolute increase in neutrophil counts are associated with worse OS .
In LAPC patients, baseline neutropenia and absolute increase in neutrophil count are associated with worse OS.
Original source:
Schernberg Antoine, Vernerey Dewi, Goldstein David et al.
org/10.
1016/j.
ijrobp.
2021.
01.
052" target="_blank" rel="noopener">Predictive Value of Neutrophils Count for Local Tumor Control After Chemoradiotherapy in Patients With Locally Advanced Pancreatic Carcinoma in this message
