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20, 2020 /--- stroke is currently one of the leading causes of long-term disability in the United States.
stroke can lead to paralysis on one side of the body, as well as speech, vision problems and memory loss.
recently, researchers at the UConn School of Medicine published a paper in the journal NeuroOlogy that found receptors involved in successfully suppressing stroke and recovery from injury after a stroke.
ischemic stroke when the arteries of the brain are blocked (photo source: www.pixabay.com), which accounts for 87 percent of all strokes.
the amount of blood and oxygen entering the brain is significantly reduced, leading to damage or death of brain cells.
released excessive amounts of ATP from damaged or dying brain cells, causing their reception P2X4 (P2X4R) to be overstimimed.
when P2X4R is overactive, it can cause a series of harmful effects in brain cells, leading to ischemic brain damage.
study, researchers found that inhibition of P2X4R regulates the inactiveization of an immune cell that play an important role in the inflammatory response to stroke.
by blocking receptor activity, the researchers found that excessive immune responses were effectively inhibited to improve the recovery of acute and chronic strokes.
mouse model, the researchers observed improved balance and coordination and reduced anxiety after intervention.
, the authors found that P2X4R inhibitor therapy reduces the total number of leukocytes that are white blood cells that promote ischemic damage when excessive.
the treatment effectively reduced cell surface expression and activation of P2X4R in brain tissue after stroke damage, without reducing its total protein level.
technology will have a significant impact, as there are currently no effective drugs on the market for stroke damage, with the exception of a few narrow, soluble blood clots or methods for removing blood clots.
(bioon.com) Source: New mechanism for stroke treatment show proof-of-concept Source: Pranay Srivastava et al. Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke, Experiment Neurology (2020). DOI: 10.1016/j.expneurol.2020.113308.
