Influencing factors of high speed mixed granulation mechanism

Generally speaking, the particles made by wet mixed granulation have irregular shape, uniform particle size distribution, and perfect structure compared with other traditional granulation processes However, the finished products of granulation involve many factors Now the influence is briefly described 1 The influence of impeller and cutter speed can be said that the size and distribution of particle size is directly related to the impeller and cutter speed When the cutter speed is slow, the particle size becomes larger, while when the cutter speed is fast, the particle size becomes smaller; when the impeller speed is slow, the particle size is smaller, and when the impeller speed is fast, the particle size is larger, the effect of the two is opposite 2 Impact of mixing and granulating procedures and time In the operation of the high-speed mixing granulator, the rotation of the stirring paddle makes the materials in the pot roll to the space, so that the materials at the bottom of the pot are thrown up along the wall of the pot This action pushes the soft materials one after another to the fast cutting knife, and is cut into particles of different sizes As the particles roll with each other for a period of time, they are rounded and gradually spherical It can be seen that the speed and time of the impeller and the cutter affect the particle size 3 The influence of material and concentration in the production of wet mixed granulation, alcohol granulation or dextrin adhesive granulation are often used, and the viscosity of the two is different from each other It is common to use alcohol to make granules, which are small and fine and easy to dry Because alcohol does not have viscosity, and it has a loose effect, this method is ideal for making granules of high viscosity traditional Chinese medicine When dextrin is used to make granules, the granules are large and coarse, and the drying is slow Because dextrin has viscosity and polymerization, this method is ideal for western medicine without viscosity In addition, whether using concentrated extract as material after dilution, or using dextrin or other binders, when producing smaller particles, the slurry concentration of the material can be diluted a little, and when larger particles are needed, the slurry concentration of the material can be slightly thicker.