Infection immune: revealing the pathogenic mechanism of Helicobacter pylori

February 13, 2020 / BIOON / -- recently, an international magazine, infection and immunology, entitled "biological energy requirements for Helicobacter pylori CAG type IV secret system dependent alternations in gastric epithalial In cells' report, scientists from Vanderbilt University revealed the pathogenesis of Helicobacter pylori through research Photo source: cc0 public domain Helicobacter pylori is planted in the stomach of nearly half of the world's population, which will increase the risk of cancer Helicobacter pylori contains a cluster of genes called cagpai, which are directly related to the high risk of gastric cancer; these strains can synthesize a complex molecular machine called type IV secretion system (T4SS), which can inject the oncoprotein named CagA and other bacterial products into gastric cells Now we have elucidated the key role of the energy producing ATPase protein, a key component of the type IV secretion system, in the bacteria, said Aung SOE Lin, MD Three kinds of ATPases, called CAG alpha, CAG beta and cage, are necessary for the transport of CagA to host cells In contrast, only two ATPases need to be injected with other bacterial products to stimulate inflammatory signals Finally, the researchers pointed out that the results may help scientists understand how Helicobacter pylori can use energy sources through complex molecular machines to correlate with the pathological mechanism of gastric cancer Original sources: Aung SOE Lin, Samuel D R dooyema, Arwen E Frick Cheng, et al Biological energy requirements for Helicobacter pylori CAG type IV secret system dependent alternations in gastric epithelial cells, infection and immunity (2019) Doi: 10.1128/iai.00790-19