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Approaching New Year's Day 2023, the Department of Respiratory and Critical Care Medicine of Henan Provincial People's Hospital will receive more than 800 new crown patients a day, "equivalent to the 800 beds per day of the respiratory department is full, and it needs to be expanded", said Zhang Xiaoju, director of the Department of Respiratory and Critical Care Medicine of Henan Provincial People's Hospital, who said that on December 28, more than 50 new crown patients visited her outpatient clinic in one morning, of which more than 30 needed to be hospitalized
.
The situation of Henan Provincial People's Hospital is also a common phenomenon
in medical institutions across the country.
With the advancement and gradual liberalization of the policy, the new crown infection rate has risen
sharply.
A large number of critically ill patients have poured into medical institutions, causing a temporary run on medical resources
.
Not only that, the unknown and panic of the new crown has made many people become "headless flies" in medication, blind hoarding of medicine, for a while ibuprofen, Lianhua Qingwen, acetaminophen have become hard currency on the market, and a drug is difficult to find
.
In previous interviews, some pharmaceutical company leaders predicted that although the impact of the new crown is gradually decreasing, the new crown itself will not disappear, there may be a new round of impact, and will continue to affect the work and life
of each of us in a new form of mutation.
In the new situation of continuing to coexist with the new crown in the future, how will we face possible infections and superinfections?
of each of us in new forms of mutation.
PART 01 IBUPROFEN VS NEW CROWN ORAL MEDICINE, HOW TO USE?
PART 0PART 1 IBUPROFEN VS NEW CROWN ORAL MEDICINE, HOW TO USE?In recent days, a screenshot of "XBB.
1.
5 strain has become the number one epidemic strain in the United States, everyone should stock up on montmorillonite powder, whole intestine raw and other drugs" has been widely forwarded, and there are rumors on the Internet that after the adjustment of China's entry policy, XBB.
1.
5
It may be introduced in large quantities and "mainly attack the cardiovascular and cerebrovascular and digestive systems, which may cause diarrhea", causing people to rush to buy related drugs
.
Subsequently, the antidiarrheal drug montmorillonite was immediately snapped up in pharmacies in many places across the country until it was out of stock, and "montmorillonite sand" was also on Weibo hot search
.
This is not the first time that new crown-related news has triggered a "hoarding tide"
.
There is no doubt that behind the hoarding of medicine is the importance of Chinese people's health and the panic
of the unknown new crown.
On December 26, 2022, the National Health Commission issued an announcement to rename novel coronavirus pneumonia to novel coronavirus infection
.
The three-year pandemic seems to be officially coming to an end, but the end of the pandemic does not mean the end of the new crown
.
With the introduction and implementation of optimization measures such as the "20 Articles" and "New Ten" for the prevention and control of the new crown epidemic and the implementation of "Class B and B Management", the prevention and control work has entered a new stage
.
At the same time, the number of new crown patients increased sharply, based on the general fever symptoms after infection, two antipyretic and analgesic drugs "ibuprofen" and "acetaminophen" once held high sales, but at the end of December, the new crown oral drug azvudine jumped to the top and became the hottest "KOL": topicality, demand surged
.
Therefore, some people have previously questioned, since ibuprofen can reduce fever, why use new crown oral drugs? "The mechanism of action of the two drugs is different, ibuprofen is aimed at fever symptoms, and the symptoms of fever are rooted in the virus, so it is definitely necessary to fundamentally control the replication of the virus
.
" Zhang Xiaoju said
.
Not only that, in recent days, extreme cases have been received clinically, and patients with symptoms and repeated medication have led to acute liver injury and are sent to the ICU
.
So after being infected with the new crown, when should I use what medicine? "Antivirals should be used as early as possible in the early stages of a viral infection, such as if
you have a sore throat and start a fever and a positive antigen test.
After the symptoms improve, stop the drug
as soon as possible.
If it is accompanied by other symptoms such as fever and cough, it can be treated
symptomatically.
However, because the new crown is a self-limiting disease, it is not possible to stack all drugs together
.
Zhang Xiaoju said
.
of the unknown new crown.
But at the end of December, the new crown oral drug azvudine jumped to the top and became the hottest "KOL": the topic and demand surged
.
The mechanism of action of the two drugs is different, ibuprofen is for fever symptoms, and the symptoms of fever are rooted in the virus, so it is necessary to fundamentally control the replication of the virus
.
Antivirals should be
used as early as possible in the early stages of viral infection, such as if symptoms of sore throat and fever begin and an antigen test is positive.
PART 02 Domestic Azvudine VS Imported Paxlovid, how to choose?
PART 02PART Domestic Azvudine VS Imported Paxlovid, how to choose?At present, there are three new crown oral drugs approved in China: Pfizer's Paxlovid (nematevir tablets/ritonavir tablets), Henan Real Bio's azvudine and Merck's monogravir capsules
.
It is worth noting that only Paxlovid and Azvudine have entered the "Novel Coronavirus Diagnosis and Treatment Protocol (Ninth Edition)
".
In order to improve the accessibility of new crown medicines, the joint prevention and control team of the State Council issued the Notice on Doing a Good Job in Internet Medical Services for New Coronary Pneumonia, clarifying that medical institutions can prescribe prescriptions for the treatment of new crown pneumonia-related symptoms online, and encourage qualified third parties to deliver drugs to patients' homes
.
Subsequently, both Paxlovid and Azvudine opened online consultation prescription purchase channels
in Internet hospitals.
The targets and mechanisms of action of the two products are different, and the prices are also different
.
Paxlovid consists of two drugs, nimatevir and ritonavir, of which nimatevir plays the main therapeutic role
.
Nirmatevir is currently the only new crown therapeutic drug
developed based on 3CL protease targets that has been marketed.
The previous price was 2300 yuan / box
.
Azvudine, on the other hand, acts on the new coronavirus polymerase (RdRp).
Azvudine was previously known as the "most cost-effective" new crown antiviral drug in China, and the price of medical insurance was 270 yuan per bottle
.
Azvudine tablets have completed the medical insurance network in 31 provinces across the country, and are speeding up the terminal distribution of hospitals across the country, and now cover major medical institutions across the country, including secondary hospitals and primary medical and health institutions
.
in Internet hospitals.
Azvudine was previously known as the "most cost-effective" new crown antiviral drug in China, and the price of medical insurance was 270 yuan per bottle
.
At present, Azvudine has opened the Internet medical platform channel for the first time, and patients can upload nucleic acid or antigen test results through the fever clinic of Fosun Health, WeDoctor, Ark Jianke and other Internet medical institution platforms, through online consultation with qualified doctors, and according to the patient's own condition, the doctor's judgment meets the standards for the use of the antiviral drug Azvudine, and the patient is given a prescription
.
It is understood that Fosun Pharma has reached a strategic cooperation with Real Bio and is responsible for the exclusive commercialization of azvudine
in the country.
Before the opening of the Internet prescription of new crown drugs, Fosun Pharma had reached strategic cooperation with a number of domestic business partners such as Sinopharm and China Resources Pharmaceutical, giving full play to their respective resource advantages, jointly improving the national terminal accessibility of real biological azvudine tablets, accelerating the coverage of the channel network, and contributing to the fight against the new crown epidemic
.
in the country.
Before the opening of the Internet prescription of new crown drugs, Fosun Pharma had reached strategic cooperation with a number of domestic business partners such as Sinopharm and China Resources Pharmaceutical, giving full play to their respective resource advantages, jointly improving the national terminal accessibility of real biological azvudine tablets, accelerating the coverage of the channel network, and contributing to the fight against the new crown epidemic
.
PART 03 DOMESTIC POTENTIAL "LIFE-SAVING DRUGS", WHAT IS THE EFFECT?
PART 03PART Domestic potential "life-saving drugs", what is the effect?Azvudine accelerates access to medication in the face of an increasing number of new crown infections across the country, which can undoubtedly alleviate people's psychological fear of the new crown virus, and more importantly, Azvudine, which can prevent severe illness, may become a potential "life-saving drug"
.
With the rapid spread of Omicron in China, the number of infected people has surged, and there have been more and more
panic and regrettable news in the hot search information recently.
Severe manifestations such as "white lung" and "viral myocarditis" began to enter people's field of vision, and some obituaries about academicians and celebrities are also regrettable
.
In these messages, most severe cases occur in older people
with underlying medical conditions.
It is understood that for the elderly, special groups with underlying diseases and low immunity, due to insufficient autoimmune protection, their infection often leads to the risk of
severe disease and even death.
For such patients, they should seek medical attention in time as soon as possible after infection, and use drugs scientifically, safely and rationally to reduce the risk of
severe transformation.
"Antiviral drugs are used as early as possible in the early stages of viral infection, and the drug
can be stopped after symptoms improve.
" Zhang Xiaoju introduced that antiviral treatment is best chosen in the early stage of viral infection, and the earlier the effect, the more significant
the effect.
Early removal of the virus, minimize the damage caused by viral infection, prevent complications, and achieve rapid recovery
.
Azvudine is the second oral drug approved for marketing in China after Paxlovid, and it is also the first approved oral small molecule new coronavirus pneumonia treatment drug in China, which can be used to treat adult patients
with common new coronavirus pneumonia.
Chang Junbiao, inventor of azvudine and vice president of Zhengzhou University, said in an interview with the media that azvudine, as a nucleoside analogue that inhibits viral RNA-dependent RNA polymerase (RdRp), can specifically act on the new coronavirus RdRp, thereby inhibiting viral replication
.
Azvudine has a significant antiviral effect on reducing the new coronavirus load, and is effective
for both mild and severe diseases.
the effect.
The results of clinical trials showed that in terms of significantly improving clinical symptoms, azvudine tablets can significantly shorten the symptom improvement time of patients with moderate novel coronavirus pneumonia, increase the proportion of patients with clinical symptoms, and achieve clinically effective results
.
At the same time, clinical trials have also proved that it has a good therapeutic effect
on variant strains including alpha, beta, delta, and Omicron.
However, experts also remind that when azvudine is used to treat the new crown, the recommended dose is 5mg each time for adult patients, once a day, and the course of treatment is no more than 14 days
.
At the same time, patients should use drugs under the guidance of physicians, and before doctors prescribe the drug, they should be familiar with the patient's contraindications, adverse reactions, drug interactions, etc.
, and ask the patient in detail about the patient's drug allergy history to avoid the use
of patients with contraindications.
on variant strains including alpha, beta, delta, and Omicron.
