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Improving Bone Marrow and Stem Cell Transplants in Patients with Blood-Related Disorders

 Last Update: 2022-04-28
 Source: Internet
 Author: User

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In adults, hematopoietic stem cells are present in the bone marrow and blood, but before birth, they are present to a greater extent in the liver, where they multiply or multiply into additional hematopoietic stem cells at a very high rate

To understand what gives fetal liver hematopoietic stem cells these superior proliferation and engraftment properties, the researchers examined gene expression patterns specific to these high-potency stem cells

"This in-depth analysis shows that these stem cells express a protein on their surface called CD201, which is closely associated with this engraftment potential and can be used to isolate functional stem cells from other cell types

A better understanding of the genes involved will also help scientists reproduce hematopoietic stem cells in the lab with high transplant potential and manipulate them to be more effective against blood cell-related diseases such as sickle cell anemia, HIV and certain types of cancer

The article's second author, Dr.

Collaborators include Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F.

Journal Reference :

Kim Vanuytsel, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F.

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