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foodmate.
net/tag_1821.
html" class="zdbq" title="Sugar-related food information" target="_blank">Carbohydrate compounds are one of the three basic substances of life, and they play an important role in many life processes, such as bacterial and virus infection, cell growth and proliferation, immune response and so on.
And gene regulation by foodmate.
net/tag_4780.
html" class="zdbq" title="Bio-related food information" target="_blank">organisms as compared to the synthesis of proteins and DNA (the DNA), synthetic carbohydrates are not biologically gene regulation, but the endoplasmic reticulum and Golgi apparatus and gradually by the enzyme-translational modification process , Which leads to the inhomogeneity and extremely diverse structures of carbohydrate compounds.
It is a very arduous task to separate and extract pure and homogeneous carbohydrate compounds from nature.
foodmate.
net/tag_4633.
html" class="zdbq" title="Chemical related food information" target="_blank">Chemical synthesis is an effective and scalable method to obtain pure and structure-determined carbohydrate compounds, which can further study its functions and develop new therapeutic drugs.
In addition, nucleosides are also a very important class of biomolecules, which play a very critical role in many cellular processes, such as enzyme metabolism and regulation, cell signal transduction, and DNA and RNA synthesis.
Nucleoside natural products and analogs often have strong anti-cancer, anti-viral and anti-bacterial activities.
Efficient synthesis of nucleoside compounds can accelerate the development of anti-cancer and antiviral drugs, DNA sequencing and understanding of their mechanism of action.
However, due to the regional and stereoselectivity problems in the synthesis of carbohydrate compounds, the low solubility and weak nucleophilicity of nucleobases in the synthesis of nucleoside compounds, how to achieve efficient synthesis of carbohydrates and nucleoside compounds remains a challenge The problem.
net/tag_1821.
html" class="zdbq" title="Sugar-related food information" target="_blank">Carbohydrate compounds are one of the three basic substances of life, and they play an important role in many life processes, such as bacterial and virus infection, cell growth and proliferation, immune response and so on.
And gene regulation by foodmate.
net/tag_4780.
html" class="zdbq" title="Bio-related food information" target="_blank">organisms as compared to the synthesis of proteins and DNA (the DNA), synthetic carbohydrates are not biologically gene regulation, but the endoplasmic reticulum and Golgi apparatus and gradually by the enzyme-translational modification process , Which leads to the inhomogeneity and extremely diverse structures of carbohydrate compounds.
It is a very arduous task to separate and extract pure and homogeneous carbohydrate compounds from nature.
foodmate.
net/tag_4633.
html" class="zdbq" title="Chemical related food information" target="_blank">Chemical synthesis is an effective and scalable method to obtain pure and structure-determined carbohydrate compounds, which can further study its functions and develop new therapeutic drugs.
In addition, nucleosides are also a very important class of biomolecules, which play a very critical role in many cellular processes, such as enzyme metabolism and regulation, cell signal transduction, and DNA and RNA synthesis.
Nucleoside natural products and analogs often have strong anti-cancer, anti-viral and anti-bacterial activities.
Efficient synthesis of nucleoside compounds can accelerate the development of anti-cancer and antiviral drugs, DNA sequencing and understanding of their mechanism of action.
However, due to the regional and stereoselectivity problems in the synthesis of carbohydrate compounds, the low solubility and weak nucleophilicity of nucleobases in the synthesis of nucleoside compounds, how to achieve efficient synthesis of carbohydrates and nucleoside compounds remains a challenge The problem.
foodmate.
net/tag_5027.
html" class="zdbq" title="China-related food information" target="_blank">China Ke Xueyuan Kunming Institute of Botany, synthesis of natural products chemistry team Xiao Zhi research group mainly in the sugar chemical synthesis research in the following two aspects: (1) the development of new methods of chemical synthesis of sugar and a new strategy; (2) has important biological activity Carbohydrate natural products undergo chemical synthesis and biological activity research.
net/tag_5027.
html" class="zdbq" title="China-related food information" target="_blank">China Ke Xueyuan Kunming Institute of Botany, synthesis of natural products chemistry team Xiao Zhi research group mainly in the sugar chemical synthesis research in the following two aspects: (1) the development of new methods of chemical synthesis of sugar and a new strategy; (2) has important biological activity Carbohydrate natural products undergo chemical synthesis and biological activity research.
In 2020, the research group reported a new method of foodmate.
net/tag_3040.
html" class="zdbq" title="Glycoside related food information" target="_blank">glycosylation reaction that can be applied to the efficient synthesis of glycosides and nucleosides based on glycosyl 1-phenylalkenyl benzoate (PVB) (Nat.
Commun.
2020, 11, 405), and applied the new one-pot glycosylation strategy based on Yu's glycosylation reaction developed by this research group to achieve the first total synthesis of guava polysaccharide 19 sugar with potent anti-diabetic effect (Angew.
Chem.
Int.
Ed.
2020) , 59, 7576; Org.
Lett.
2019, 21, 2335).
Recently, the research group reported for the first time a new sugar assembly strategy for one-pot glycosylation reaction of both oxoside and nucleoside based on glycosyl PVB.
In addition, the application of this new sugar assembly strategy has achieved the total synthesis of the nucleoside antibiotic capuramycin with anti-tuberculosis activity, TMG-chitotriomycin with fungicidal and insecticidal activity, and one of the important endosymbiotic lipid chitosan oligosaccharides (lipochitooligosaccharides).
Synthesis by pot method.
This synthetic route represents one of the most direct and efficient routes to synthesize such molecules.
This research result was recently published in the flagship journal "Chemical Science" of the Royal Society of Chemistry (Chem.
Sci.
2021, DOI: 10.
1039/D0SC06815B).
The first author of this research is Dr.
He Haiqing and Xu Lili as master students.
net/tag_3040.
html" class="zdbq" title="Glycoside related food information" target="_blank">glycosylation reaction that can be applied to the efficient synthesis of glycosides and nucleosides based on glycosyl 1-phenylalkenyl benzoate (PVB) (Nat.
Commun.
2020, 11, 405), and applied the new one-pot glycosylation strategy based on Yu's glycosylation reaction developed by this research group to achieve the first total synthesis of guava polysaccharide 19 sugar with potent anti-diabetic effect (Angew.
Chem.
Int.
Ed.
2020) , 59, 7576; Org.
Lett.
2019, 21, 2335).
Recently, the research group reported for the first time a new sugar assembly strategy for one-pot glycosylation reaction of both oxoside and nucleoside based on glycosyl PVB.
In addition, the application of this new sugar assembly strategy has achieved the total synthesis of the nucleoside antibiotic capuramycin with anti-tuberculosis activity, TMG-chitotriomycin with fungicidal and insecticidal activity, and one of the important endosymbiotic lipid chitosan oligosaccharides (lipochitooligosaccharides).
Synthesis by pot method.
This synthetic route represents one of the most direct and efficient routes to synthesize such molecules.
This research result was recently published in the flagship journal "Chemical Science" of the Royal Society of Chemistry (Chem.
Sci.
2021, DOI: 10.
1039/D0SC06815B).
The first author of this research is Dr.
He Haiqing and Xu Lili as master students.
