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Importance of reverse screening for new drug discovery

 Last Update: 2022-03-10
 Source: Internet
 Author: User

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Earlier this year, the journal "Nature Catalysis" published a Chinese scientist's discovery of the Suzuki reaction catalyzed by amines.

Drug source analysis

Trace impurities interfere with scientific observations not only in the catalysis of coupling reactions, but also in medicinal chemistry.

Unlike tracking strategies such as me-too and me-better, which have high-quality leads at the beginning, you start from scratch in the development of new target drugs

With the target protein and compound library for screening, the next task is to design the screening criteria (assay)

The first thing is to look at the purity of your compounds.

Some compounds cannot be optimized even if the activity really comes from the compound pointed to by the formula

Some protein-ligand binding methods are also difficult to optimize, such as allosteric inhibitors

Even if you have experienced 9981 difficulties to enter the clinic, the chance of Buddha getting you listed is less than 10%, but this is a good problem to have

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