Immunol Rev: Long-life plasma cell formation is critical to vaccine efficacy!

, July 5, 2020 /
Biovalley
BIOON/- Monash University has looked at the effects of plasma cells and their life span on vaccine effectiveness in the human body, and concluded that components in vaccine design are keyafter the outbreak of COVID-19, many studies have focused on the development of vaccinesThere are two things you have to do if vaccines are to succeedFirst, it must signal the body that it produces a large number of plasma cells to make antiviral antibodiesSecond, these plasma cells must survive and produce antibodies for years or even decades before the vaccine can be successfully vaccinatedThe reality, however, is that most of them can only survive for a few daysphoto source: Professor David Tarlinton of the Immune Memory Laboratory at Monash UniversityMonash University Center Clinical School recently published a study in the journal immunereview s at the, which suggests that ingredients in vaccines can play an important role in extending the life of individual slurry cellsUnderstanding the process of long-life plasma cell formation will provide a more effective method for vaccine productionOne of the difficulties ofdesigning an effective vaccine is that it is not clear what determines how long a single plasma cell will surviveWe have limited understanding of what makes pulp cells that survive longer and what keeps them alive during their developmentthe paper goes a step further in concept and outlines the potential for survival clues between plasma cells, so there may be a "survival of the fittest" long-term antibody immunityDr Marcus Robinson, a researcher at Monash University in 's Tarlinton lab, said the paper outlines a framework that can be used to identify a single signal that causes long-term antibody reactions in pulp cells "It's exciting that we're at the cutting edge of understanding this complex set of events that could be used in vaccine design in the near future," he said (BioValleyBioon.com) References: Unlocking the key to an effective vaccine
Marcus J Robinson et al.
How ar y extrinsic regulators of plasma cell survival o sy'n intersect for good ei , immunity i'r myso reviews (2020) DOI: 10.1111/imr.12895