-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Caloric Restriction (CR) refers to restricting the intake of only a small amount of limited energy per day under the condition of fully guaranteeing the nutritional components of the organism (such as essential amino acids, vitamins and various trace elements.
But are these benefits the same in humans?
On August 12, 2022, Yale University researchers published a research paper titled: The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging in the Cell sub-journal Immunit.
The study shows that moderate calorie restriction can reduce the production of an aging-related protein SPARC, thereby suppressing harmful inflammation and improving the health of the elderly, suggesting that calorie restriction may help prolong healthy human lifespa.
The study, led by Professor Vishwa Deep Dixit, director of the Yale Center for the Study of Aging, further analyzed data from an NIH-funded clinical trial in a study titled "Comprehensive Evaluation of Long-Term Effects of Reduced Energy Intake (CALERIE.
The research team hopes to find molecules that positively affect caloric restriction as therapeutic target.
After a year or two, the team analyzed changes in the participants' adipose tissue and found that those who were calorically restricted had significantly greater expression of the protein cysteine-rich acidic protein (SPARC) in their adipose tissu.
Since inflammation plays an important role in age-related decline, the research team wanted to learn more about whether longevity interventions like caloric restriction play a role in controlling inflammation and immune responses through SPARC protein.
Therefore, the research team further studied the effect of SPARC protein on mouse immune cells and health in mic.
What's more, lowering the SPARC protein produced by the mice's fat cells reduced inflammation, improved metabolism, and extended the healthy lifespan of the mic.
Professor Vishwa Deep Dixit, the corresponding author of the paper, said that this study revealed that SPARC protein affects inflammation and healthspan through the regulation of macrophage.
Original source:
Seungjin Ryu, et a.
