Immunity: uncovering the molecular mechanism of T cells communicating with each other, which is expected to help develop new anticancer therapies

February 17, 2020 / BIOON / -- recently, an international magazine, immunology In the previous research report, scientists from institutions such as the University of Leiden found that T cells in the immune system can communicate with each other and cooperate as a team to play a role In order to resist the infection of the body, they will stimulate each other's growth At the same time, when T cells are surplus, they will inhibit each other Relevant research results or develop new cancer therapy for researchers Law provides new ideas and hopes Image source: Jan, immunology researcher Rohr said that in this study, we have carried out in-depth research on T cells These cells will not act independently as individuals They can work together as a team, which is very important for a healthy immune system In order to resist external infection, the body must have enough immune cells, but more does not mean better Too many immune cells will damage the healthy tissues of the body This is why T cells work together in an ingenious way, but successful cooperation also requires communication The researchers found that these T cells can sense each other and communicate with each other in a timely manner In the case of infection, these cells will not only give T cells to promote reproduction and growth, but also transmit signals to each other With the increase of T cells, the content of information transmission between cells will follow In the end, once the cells stop reproducing, the inter cell system will realize self-regulation Relevant research results may be helpful for the development of new immunotherapy for cancer Tumor will protect itself by inhibiting the function of immune system In specific therapy, researchers will remove T cells from patients' body, promote their reproduction and enhance their function in the laboratory, and finally import them into patients In principle, a large number of T cells imported into patients' body will reach the maximum Large effect; researcher beltman explained that repeated use of a small number of T cells may be more effective than single use of a large number of T cells against tumors Cells, in this case, may not shut down each other's communication mechanism, but this is a high-dose risk, and the extent to which the research findings can help change the current immunotherapy remains to be further studied by scientists In this study, researchers used microscopes in the laboratory to delay imaging and genetics Analytical techniques are used to study immune cells, and then researchers use the information found to create a computer model to describe the interaction between different cells In this way, researchers can clarify the quantitative relationship between the signals of promoting and inhibiting growth transmitted between T cells and the number of T cells At last, researcher beltman said that this may be able to help predict how many T cells will be activated based on signals The most popular researchers are expected to detect this special mechanism in animal models Later researchers need to conduct more in-depth research to reveal the interconnection mechanism between T cells, so as to help develop a variety of new anti-cancer therapies Original source: Simon Zenke, Margaret M palm, Julia Braun, et al Quorum regulation via nested anti feedback circuits mediated by the receivers CD28 and CTLA-4 conferences robotics to T cell population dynamics, Immunology (2020) Doi: 10.1016/j.immuni.2020.01.018