Immunity: Researchers map the development of human T-cells

, July 7, 2020 /PRNewswire-BIOON/ -- Chintan Parekh, M.D., of the Saban Institute at Los Angeles Children's Hospital, led a team that has drawn up a comprehensive roadmap for how T-cells develop in human thymusThe study will be published in the journal ImmunityT-cells are white blood cells that participate in an immune response against intruders such as pathogens or cancer cellsUnderstanding the development of human T-cells is essential for the treatment of diseases caused by abnormal development of T cells, such asleukemiaand immunodeficiency, and the development of effective immunotherapy such as CAR-Talthough most previous studies have been done in mice, the study clearly reveals high-resolution images of human T-cell developmentBecause of biological differences between species, it is essential to study human T-cells in order to obtain the information we need to understand human diseases and to design new immunotherapypicture source: Using single-cell sequencing techniques to study cells isolated from human thymus tissue, the researchers mapped t-cells at different stages of human thymus development, including multiple genes that are turned on or off at each stageThey mapped the different developmental routes that the most immature cells in the thymus might take as they matured, and found specific stages of development and genetic activity patterns in humansthis understanding will contribute to a deeper understanding of diseases caused by T-cell defects or abnormal T cells, such as immunodeficiency disease (severe combined immunodeficiency disease or SCID), T-cell-mediatedautoimmunediseases (type 1diabetes, rheumatoid arthritis) and leukemia (T-cell acute lymphoblastic leukemia)these findings could also help the development of immunotherapy, such as CAR-T therapy, which is considered one of the most important advances in cancer treatment We also need to learn more about the development of T-cells to advance treatment and accelerate the recovery of the immune system after a bone marrow transplant in patients with cancer and other diseases (BioValleyBioon.com) References: Researchers Generate Developmental Map of Human T-cells Justin Leet al, -Cell RNA-Seq Mapping of Human Thymopoies Reveals Lineage Trajectories and aspec sspecble in T Spectrum , Imm DOI: 10.1016/j.immuni.2020.05.010
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