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Illustrate what is dyskinesia caused by levodopa

 Last Update: 2021-12-26
 Source: Internet
 Author: User

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Patients with Parkinson's disease may develop dyskinesia after taking levodopa for a long time
.

Dyskinesia is a dance-like, agitated or simply repetitive involuntary movement that mainly affects the trunk and limbs, and can also appear on the head and face

1.
Peak dosage form: It is caused by the increase of dopamine concentration in the nerve synaptic cleft and the excessive excitement of dopamine receptors after taking the medicine
.

The movement of the limbs can start from the foot on the side with severe symptoms

It may be related to the instability of blood concentration caused by the decreased storage capacity of dopamine

2.
Biphasic type: Appears at the beginning of the drug's onset and at the end of the dose.
It usually occurs in PD patients with a long course of disease, and often secondary to the peak-type dyskinesia
.
It may be related to the instability of blood concentration caused by the decreased storage capacity of dopamine
.
It can increase the single dose and number of doses of levodopa preparations, and increase dopamine receptor agonists or catechol oxygen methyltransferase (COMT) inhibitors
.
3.
Off-phase dystonia: mostly occurs in the morning when the blood concentration of levodopa is low before taking the medicine
.
Long-acting levodopa preparations or dopamine receptor agonists can be taken before going to bed
.
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