IDH wild 胝 surgical treatment of glioblastoma

glioblastoma (ccGBM) is a rare malignant brain tumor with rapid clinical symptoms and poor prognosis.
has long been ineffective in surgical treatment.
recent studies have shown that extensive excision can improve survival rates in ccGBM patients, but there is a lack of research on molecular characteristics.
Franco, of Neurosurgery at the University medical center in Freiburg, Germany, conducted retrospective studies of ccGBM patients treated at the medical center between 2005 and 2017 to analyze the efficacy and prognosis of tumor removal and complementary treatment of IDH wild ccGBM.
results were published online in October 2020 in Acta Neurochir.
study methodglioblastoma has characteristic growth patterns that more or less invade both hemispheres of the brain.
most commonly located in the forehead, can also be in the top leaf and pillow leaf.
if the two hemispheres are almost equally soaked, it is called butterfly glioblastoma, which is clinically manifested as a directional disorder, reactive epilepsy, coma, or silence.
because the tumor invades the functional area, full removal is very difficult.
in the past to biopsy diagnosis of tumors and molecular genetic testing.
recent studies have shown that ccGBM excision can extend total survival without aggravating persistent neurological dysfunction.
the authors screened IDH wild ccGBM patients older than 18 years of age through MRI imaging, confirmed by histological pathology and molecular gene analysis, and divided into three groups: tumor full cut, sub-full cut and stereotactic biopsy.
30 patients (54.6%) confirmed histological diagnosis through biopsies, 50% of whom received simple chemotherapy or radiotherapy plus chemotherapy.
25 patients had tumor removal, 8 of which were total and 17 were partially removed.
the main determinant of tumor excision is its placeholding effect.
patients in both the surgical and biopsy groups showed significant improvement in postoperative KPS, and follow-up over 3 and 12 months found that the number of patients in the biopsy and sub-full-cut group KPS<80 increased, while the number of patients in the full-cut group increased significantly in 60% of patients with KPS>80 in 3 months and only 5 KPS>80 in 12 months, no significant difference from the other groups.
analysis of various factors showed that the medium total survival of patients in the tumor whole-cut group was better than that of the sub-full-cut group and the biopsy group.
even tumor maximization reduces the placeholding effect and helps improve the prognostication of patients.
The results show that it is feasible to remove IDH wildglioma, which can significantly improve the total survival.
remove the tumor to the maximum extent possible, does not necessarily lead to the deterioration of nerve function.
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