I know what your mother experienced in order to give birth to you!

May 12, 2019 / BIOON / - today is mother's Day - the second Sunday of May 12 and may I wish you a happy mother's Day! Beside your mother, can you accompany your dear mother and share the housework for her? You are far away, can you call your mother who loves you the most, and send the blessing of the festival? Photo source: https://cn.bing.com remember to be a quiet and filial baby from today on: if you stay with your mother, please don't quarrel with her, if you are in a foreign country, please go home often! Because you never know, what did your mother go through to give birth to you? The following research may help you understand! 【1】 Human reproduction: shock! Give birth to children or let mother telomere age for 11 years! Doi: 10.1093/humrep/dey024 a new study by researchers in the Department of global and community health at George Mason University found that women who had children had shorter telomeres than women who had not Telomeres are caps at the ends of DNA on our chromosomes that help DNA replicate, but shorten over time Previous studies have found that telomere length is associated with incidence rate and mortality, but this study is the first to examine the relationship between telomere length and birth Their findings are published in human reproduction The researchers report that women who have had children have telomeres that are the same length 11 years later In other words, having children has aged women by 11 years This change in telomere length is even greater than the reported change in telomere length caused by smoking or obesity Professor Anna Z Pollack, who led the study, said: "despite these data, we cannot conclude that having children is related to telomere shortening, or that only those women who have had children begin to have shorter telomeres." Other factors that need to be considered include stress and social support, as well as whether there are similar phenomena in men This article uses data from the national health and nutrition survey, a nationally representative study conducted in the United States Pollack said the findings "are preliminary and need further study to confirm." The study was jointly conducted by Kelsey rivers, who completed the study at the undergraduate research project award of George Mason University, and pollack 【2】 Really? Having a child may increase your mother's risk of heart disease doi: 10.1089/jwh.2018.7161 having a child will bring you stress, and the more children you have, the more stress you have to manage, but that's not all More children will not only increase stress, but also the risk of cardiovascular disease, according to recent studies The study, from the community atherosclerotic risk study (ARIC), followed more than 8000 women from the United States for 30 years and found that the more children women have, the higher their risk of later heart disease, stroke and heart failure Compared with women with only one or two children, women with five or more children suffer from the above The risk of disease increases by 26% There are several reasons that may explain why children are related to women's cardiovascular disease Women's bodies will change dramatically during pregnancy, not only in their stomachs, but also in their hearts, which will increase by 12% after 9 months, which will help to cope with the increase of 50% of the blood flow in the body These great changes reflect the great needs of women during pregnancy Although everything can return to normal after birth, it may have a long-term impact on their health Photo source: https://cn.bing.com not only does pregnancy have a negative impact on women's physical health, but anyone with children may tell you that women have almost no leisure time outside of taking care of their children, family life and work, so how can they socialize? The less time women spend taking care of themselves, getting enough sleep and relaxing, the more likely they are to seek quick solutions, such as picking up biscuits, drinking a glass of wine and relaxing, which may become one of the factors affecting women's health All of these studies may lead to the idea of postponing childbearing, but sometimes it may be good news that having children may not be completely harmful to the health of the body, which may be beneficial to the health of the brain and heart of the body, and it can also help effectively prevent the occurrence of certain cancers, whether breast-feeding or not The more children a woman has, the more she has ovarian cancer and The less likely some types of breast cancer are 【3】 Ann int Med: really? Having children may increase a woman's risk of breast cancer! Doi: 10.7326/m18-1323 recently, in a research report published in the international journal Annals of internal medicine, scientists from the Lineberger comprehensive cancer center at the University of North Carolina found through a large-scale analysis that recently, young women who have just had children are more likely to have sex than women of the same age who have not had children or have breast cancer The findings seem to contradict the traditional view that childbirth can help women effectively prevent breast cancer The researchers say childbirth still has a protective effect on women, but it may take more than 20 years to produce certain benefits Breast cancer is a common type of cancer among elderly women, and the average age of breast cancer women in the United States is 62 years , the researchers found that women who had children under the age of 55 had an increased risk of breast cancer Photo source: hazel B, researcher, https://cn.bing.com Dr Nichols said that most people know that women with children have a lower risk of breast cancer than women without children, but this research conclusion comes from the research results of women aged 60 and above In this study, researchers found that it may take 20 years to provide women with prevention benefits against breast cancer after giving birth Before that, just Women who live with children may have a higher risk of breast cancer The researchers collected data from 15 prospective studies around the world, including 889944 women In addition to analyzing the breast cancer risk of these women after giving birth, the researchers also evaluated the impact of other factors, such as breastfeeding and family history of breast cancer They found that among women aged 55 and under, the risk of breast cancer peaked five years after giving birth Compared with women who had not given birth, the risk of breast cancer among these women was 80% higher; after 23 years of childbirth, the risk of cancer among women decreased, and the protective effect of childbirth began to play a role, for those with breast cancer The risk of breast cancer after childbirth may be higher for women with ethnic history, women with more children or women with older birth age, and this pattern seems to be the same whether they choose breastfeeding or not The results of this study do not apply to all young women Women who give birth to their first child after the age of 35 will have a higher risk of breast cancer, while women who give birth before the age of 25 will not have an increased risk of breast cancer after the latest delivery Although pregnancy has a protective effect on breast cancer with positive estrogen receptor, the researchers found in the research process that it seems to have a protective effect on breast cancer with positive estrogen receptor Estrogen receptor negative breast cancer individuals had no protective effect The researchers pointed out that the risk factors of young women's breast cancer seem to be different from those of old women There are different types of breast cancer, and the risk factors that develop into one type and another may not be the same The results of this study can also be used to help researchers develop breast cancer risk prediction models, so as to guide the accurate screening and prevention of breast cancer Development of sexual strategies Nichols, the researcher, said that in many ongoing studies, researchers are trying to predict the risk of breast cancer at the individual level, which may be used as evidence to help establish a new breast cancer risk prediction model 【4】 SCI Rep: multiple pregnancies make women's cells age faster DOI https://doi.org/10.1038/s41598-018-29486-4 a recent study by researchers from Northwestern University showed that women with multiple pregnancies are more likely to age The study, by researchers such as Calen Ryan of Northwestern University, reveals why women with multiple children are more likely to show signs of aging The results were published in the latest issue of scientific reports, in which the authors studied two markers of cell aging: telomere length and epigenetic age The results show that every time a woman experiences pregnancy, her cells will age by 0.5-2 years In addition, the researchers found that women in the early stages of pregnancy had younger cells than expected Looking at historical and epidemiological records, the authors found that women with more than one child lived shorter lives and had different types of diseases than other women "Our study suggests that changes in cells during pregnancy may be related to changes in the mother's immune system However, there are many things we don't know For example, we don't know whether this relationship will always exist and play an important role as we grow older " In order to study this problem, the researchers plan to conduct a long-term study on the same group of women for 13 years in the future 【5】 JNCI cancer spectrum: the number and age of pregnancies affect women's risk of breast cancer doi: 10.1093/jnics/pky078 researchers from the Melman School of public health at Columbia University and the National Institutes of health in Paris confirmed that the risk of breast cancer in multiple pregnancies and breastfeeding is low and the average risk of women is the highest According to the largest prospective study of BRCA1 and BRCA2 mutation carriers to date, breast cancer Women who had BRCA1 mutations and had two, three or four or more full-term pregnancies had a 21%, 30% and 50% lower risk of breast cancer than women who had a single full-term pregnancy Breastfeeding also reduces the risk of BRCA1 mutation carriers The results were published in Journal of the National Cancer Institute cancer spectrum In contrast, women with BRCA2 mutations did not reduce the risk of multiple pregnancies unless they had four or more pregnancies Women with BRCA1 mutations who had only one full-term pregnancy had an increased risk of breast cancer, while women with BRCA2 mutations had fewer than four pregnancies Photo source: https://cn.bing.com "What we know is that time is very important for many risk factors We see a double effect of pregnancy in non mutation carriers, with long-term protection, but the short-term increase after pregnancy may not extend to all BRCA1 and BRCA2 mutation women, because the short-term increase and long-term protection may be more related to the time of these pregnancies," lead author Mary Beth Terry, PhD, Professor of epidemiology and Environmental Health Sciences at Mailman School of public sciences Columbia University and Herbert Owen Comprehensive Cancer Center for health "In addition, hormonal upheavals during the first pregnancy may have more or less important effects on the risk of breast cancer