Hypoxia thinking after three months of squatting

Hypoxia, as the Nobel Prize for 19 years, is undoubtedly a research hotspot in recent years.

But being a hot spot means that there are definitely not few related studies or articles.

It is more difficult to find the right ideas that others have not done before.

In December last year, when the editor saw this hypoxia-related article, he did not pay special attention to it, because it felt it was very common, and it must have been studied by many people.
If you study it again, it will be easy to crash.

However, after three months, when the editor kept inquiring about relevant ideas, I found that in addition to the cancer types studied in this article, only three cancer types have been done, and they are all different from this article, and the magazine level is at two points.
many.

Therefore, the importance of today's hypoxia thinking is self-evident.

In addition to breast cancer, if you want to post quickly, collect it quickly.

The article was published in Frontiers in Oncology (IF: 4.
848) in December.

Shengxin people provide novel and reproducible hypoxia-related life information analysis and are interested in scanable Hypoxia-Associated Prognostic Markers and Competing Endogenous RNA Co-Expression Networks in Breast Cancer Hypoxia-Associated Prognostic Markers and Competing Endogenous RNA Co-Expression Networks in Breast Cancer.
: Many primary tumors have insufficient supply of molecular oxygen, which is called hypoxia.

Hypoxia is one of the main characteristics of solid tumors, leading to a higher risk of local failure and distant metastasis.

It is very necessary to study the molecular markers related to hypoxia in breast cancer.

2.
Material method: TCGA BRCA, METABRIC, miRbase, ImmuCellAI, ConsensusClusterPlus, LASSO, cox, km 3.
Results: 1.
Consensus clustering identified two BRCA subtypes with different hypoxia status Figure 1.
Consensus clustering identified two BRCA subtypes in different hypoxic states 2.
Immune cell infiltration under different hypoxic states of BRCA Figure 2.
Immune cell infiltration under different hypoxic states of BRCA 3.
Identification of differentially expressed genes and enrichment analysis Figure 3.
Identification of differentially expressed genes and enrichment Set analysis 4.
Hypoxia-related DEG prognostic markers and risk characteristics construction Figure 4.
Hypoxia-related prognostic mRNA markers and risk characteristics construction in DEG 5.
Identification of hypoxia-related differential expression candidate miRNAs and enrichment analysis Figure 5.
Identification of hypoxia Oxygen-related differential expression candidate miRNA 6.
Identify the DEG regulated by the hypoxia candidate miRNA Figure 6.
Identify the candidate gene 7.
Hypoxia-related ceRNA regulatory network Figure 7.
Hypoxia-related ceRNA regulatory network lncRNA selection Figure 8.
Hypoxia-related ceRNA Control network summary: It is important for Idea to be innovative enough, but it is as important as others not to crash.
Otherwise, when you start writing, you will find that others have already published, and you will not be able to cry when you want to cry.

Today's thinking, maybe the magazine level is only 4+.

However, hypoxic ceRNA is indeed only breast cancer has done so.

This idea is the best choice for quick posting.
It is a hot spot to study hypoxia itself.
With some other hot spots at present, functional experiments can be supplemented in the follow-up, which can easily reach 5+.

m6A, iron death is almost finished