Hypotension or induced dementia "culprit"!

October 23, 2019 news / Bio Valley bio on / -- brain function will decline with age People usually worry that brain function decline is an inevitable link in the process of aging, and it will lead to dementia, but in fact, it is not so Many people have not experienced age-related cognitive function decline After years of clinical research on the elderly, the researchers found that long-term hypotension may increase the risk of individual age-related cognitive decline For example, in 2017, researchers conducted a 27 year follow-up survey on more than 24000 people, and found that hypotension is the main predictor of cognitive decline and dementia risk, which is related to age, gender, and Weight, cardiovascular, kidney, or diabetes status were not relevant Photo source: thebluediamondgallery.com when a person is sitting or standing, hypotension is directly related to the decrease of blood flow to the brain Many researchers believe that the lack of blood supply to the brain plays a key role in the pathogenesis of dementia, Alzheimer's disease, even Parkinson's disease, and some even think it may play a major role Scientists studying the relationship between hypotension and cognitive ability need to determine what it means to have too low blood pressure, which may help health care workers effectively intervene and correct a person's hypotension What is hypotension? In one study, researchers used data from a relatively new FDA approved quantitative assessment tool to assess cognitive function in the brain of people aged 50 and over, with a high school degree or higher This computer-based assessment (each person needs about 10 minutes to complete the assessment) can provide clinicians and researchers with a repeatable cognitive function assessment, ranging from 0 to 100 When the score is more than 75, a person is usually in the range of his age expected cognitive function, while the score is between 50 and 75, which is lower than the normal range Accordingly, the patient is infatuated The risk of dementia increases, and people with scores below 50 exhibit a variety of dementia related characteristics Researchers have been comparing cognitive function scores and resting blood pressure levels of people aged 50-95 Resting blood pressure can reflect the blood pressure level of an individual after sitting for 10-15 minutes without pressure This is the blood pressure status of most American elderly people for most of the day, because they sit for more than 9 hours every day Previous researchers have found that diastolic blood pressure is a better predictor of cognitive function; researchers have found that even individuals with diastolic blood pressure higher than 60mmhg threshold can not support their normal cognitive function; indeed, in any case lower than the normal (80mmHg) diastolic blood pressure, the cognitive function of the elderly will be significantly reduced, more interestingly, the results of related studies and researchers Early reports on the harmful effects of hypotension on cognitive function are consistent, even in young people Image source: the amazing effect of Iran Daily's calf muscles drug use, heart failure or other health complications often lead to lower diastolic blood pressure, but for most people, it may be that the heart is not in every stroke In other words, low cardiac output occurs when there is not enough blood flowing back from the lower body to the heart Soleus muscle is a special muscle in the middle of regression, which is responsible for pumping blood back to the heart In the past 10 years, researchers have confirmed that soleus muscle plays a very important role in maintaining normal blood pressure An effective strategy to maintain normal blood pressure and cerebral blood flow is to retrain the soleus muscles of the body These deep-seated postural muscles are often the most active in activities such as shield or toe standing We can reconstruct these muscles through regular activities However, although this requires several hours of exercise every day Another option is passive exercise, which can train the soleus muscle more easily Whether electrical stimulation or mechanical stimulation, soleus muscle stimulation has been proved to significantly increase the venous return of the heart Initial clinical studies have confirmed that daily training of soleus muscle can improve resting diastolic pressure, which can reverse cognitive impairment related to aging for several months At present, there is no treatment for dementia, and there seems to be no potential treatment, so researchers are very concerned about how to effectively slow down or reverse cognitive aging, so as to effectively prevent the progress of dementia If the intervention to eliminate chronic low diastolic pressure is simple and direct, we may be able to eliminate the scourge of dementia to a large extent in modern society Reference materials: [1] R Peters Aging and the brain postgrad Med J 2006 Feb; 82 (964): 84 – 88 Doi: 10.1136/pgmj.2005.036665 [2] Jessica Mira Gabin, Kristian tambs, ingvild saltvedt, et al Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT study, Alzheimer's Research & Therapy volume 9， Article number： 37 (2017)， doi：10.1186/s13195-017-0262-x 【3】Frank J Wolters， Hazel I Zonneveld， Albert Hofman，et al Cerebral Perfusion and the Risk of Dementia—A Population-Based Study ， Circulation （2017）doi：10.1161/CIRCULATIONAHA.117.027448
【4】 DE NOVO CLASSIFICATION REQUEST FOR COGNIVUE 【5】Kenneth J McLeod，Teesta Jain Postural Hypotension and Cognitive Function in Older Adults ， Gerontol Geriatr Med 2017 Jan-Dec； 3： 2333721417733216 2017 Sep 25 doi： 10.1177/2333721417733216 【6】 Reversal of cognitive impairment in a hypotensive elderly population using a passive exercise intervention
【7】 Low blood pressure could be a culprit in dementia， studies suggest by Kenneth McLeod， The Conversation