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Hydroxychloroquine could be a new treatment option for erosive oral lichen planus

 Last Update: 2022-10-11
 Source: Internet
 Author: User

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Lichen planus is a T cell-mediated autoimmune disease of the skin and mucous membranes that causes erythema, atrophy, and ulceration, with an incidence of approximately 1-2% worldwide

Hydroxychloroquine (HCQS) is a wonder drug that was developed as an antimalarial drug shortly before World War II

OBJECTIVE: To quantitatively assess the effect of enteral hydroxychloroquine (HCQS) monotherapy for 6 months on the extent and severity of erosive OLP using the reticulum score, erythema score, and ulceration score (REU score), and to subjectively evaluate the success of treatment versus the severity of erosive OLP.

Setting and Design: A Prospective Clinical Trial

Study flow chart (N: number of subjects):

METHODS AND MATERIALS: A total of 45 subjects received a 200 mg HCQS bid for 6 months

One-way repeated ANOVA measures to compare mean REU, VAS, and BURN at different time intervals:

RESULTS: REU, VAS, and BURN scores decreased significantly during the study period, compared with baseline, at three- and six-month intervals (P < 0.

One year after cessation of monotherapy, follow-up of left and right buccal mucosal erosive OLP showed complete remission:

In conclusion, within the limitations of the study, it was concluded that HCQS monotherapy with a daily dose of 400 mg/day for 6 months may be a promising curative treatment for OLP-e

Reference: Raj SC, Baral D, Garhnayak L, Mahapatra A, Patnaik K, Tabassum S, Dash JK.

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