Hydrosol can help reduce inflammation and heal wounds

December 18, 2019 / Biovalley BIOON/ recently, bioengineers at Rice University developed an injectable hydrogel that promises to help heal wounds, transport drugs and treat cancer Importantly, this hydrogel does not stimulate the body's inflammatory response This new type of hydrogel is designed to be an injectable mode and simulate the function of cell scaffolds at the required locations With the passage of time, the human body naturally transfers new blood vessels and cells to the scaffold site, and degrades the original hydrosol structure, so as to restore the function of local tissues In addition, hydrogels can carry chemical or biomarkers to determine the structure of the scaffold or the affinity to surrounding tissues The study was published in the journal Biological "We have been developing peptides based hydrogels over the years and have produced about 100 different types of gels," says Hartgerink, author of the article (photo source: Www.pixabay.com) in this study, the researchers wanted to know specifically how synthetic hydrogels affect the inflammatory response of the environment "Usually, we think that inflammation is harmful, because inflammation is sometimes related to pain, and no one likes the bacterium of pain But inflammation is also important for wound healing and infection clearance We don't want inflammation to be completely zero, but we want it to be controlled " The authors tested four basic types of hydrogel - two with positive electricity, two with negative electricity - and explored what kinds of inflammation they cause They found that positively charged hydrogels were much more inflammatory than negative charged hydrogels "If the wound is to be healed, it may be better if the inflammatory response is lower However, if you want to be treated for cancer, a higher inflammatory response may be more effective For applications such as drug delivery, negatively charged materials may be better Sources of information: Hydraulics control information to help healingoriginal sources: Tania L Lopez Silva, David g leach, alon azares, i-che Li, Darren g Woodside, Jeffrey D hartgerin Chemical function of multi domain power hydraulics governments early host immune response Biomaterials, 2020; 231: 119667 doi: 10.1016/j.biomaterials.2019.119667