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Hutchison Medicine's CSF-1R inhibitor HMPL-653 capsule was approved for clinical use in China

 Last Update: 2021-12-07
 Source: Internet
 Author: User

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ArticleMedicine Guanlan

According to the latest announcement from the Center for Drug Evaluation (CDE) of the National Food and Drug Administration of China, Hutchison Medicine’s HMPL-653 capsule has just received an implied clinical trial approval and plans to develop treatments for advanced malignant solid tumors and giant cell tumors of tendon sheaths (TGCT)

Image source: CDE official website screenshot

CSF-1R is the cytokine CSF-1 receptor.

Speaking of giant cell tumor of tendon sheath, this is a rare tumor with local aggressiveness

However, for patients with giant cell tumor of tendon sheath, the current main treatment is still surgical resection.

In addition to its role in tendon sheath giant cell tumors, CSF-1R-mediated signaling pathways also play an important role in the differentiation and survival of mononuclear phagocytes, especially macrophages

At present, the global pipeline for CSF-1R access is also continuing to be promoted

Reference materials:

[1] Center for Drug Evaluation (CDE) of China National Medical Products Administration.

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