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Huibaoyuan Bio's new anti-cancer drug xylazine obtained clinical trial approval from the U.S. FDA

 Last Update: 2021-11-05
 Source: Internet
 Author: User

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Huibaoyuan was informed on August 16 that the company’s new anti-cancer drug xylazine (JP001) has been approved by the U.
S.
Food and Drug Administration (FDA) for clinical trials.
) Research
.

This study aims to evaluate the overall survival benefit and safety of JP001 combined with standard radiotherapy and chemotherapy for newly diagnosed GBM patients

Glioblastoma (GBM) is the most common type of glioma, and the prognosis of patients is poor.
Most reported median survival (OS) of 10 to 15 months
.

The current standard treatment is maximum safe resection, followed by simultaneous radiotherapy (RT) and temozolomide (TMZ) chemotherapy to the resection cavity, followed by TMZ adjuvant therapy

Autophagy is a lysosomal-mediated catabolic process that helps maintain cell homeostasis and cell survival by degrading cytoplasmic components when exposed to intracellular or external stress
.

GBM is considered to have very strong autophagy, is a tumor that is resistant to radiotherapy and chemotherapy, and its tumor microenvironment is in an immunosuppressive state

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