-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
On December 6, the internationally renowned journal eLife published an online publication titled "Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface" by Professor Liu Jianfeng’s team from the School of Life Science and Technology, Huazhong University of Science and Technology.
G protein-coupled receptors (GPCRs) are the largest cell membrane receptor protein family in the human body.
GABA B receptor specific PAM can provide help for the temporal and spatial specific regulation of the physiological effects of natural ligand GABA .
Professor Liu Jianfeng’s research group continued the previous research results and systematically studied the functional properties of the three GABA B receptor-specific PAMs in a variety of different combinations of chimeric receptors and a large number of mutant receptors using different functional experimental methods.
Figure: Schematic diagram of the molecular mechanism of GABA B receptor activation and allosteric regulation
This work is another important discovery of Professor Liu Jianfeng's research group on the mechanism of GABAB receptor activation
Professor Liu Jianfeng’s research group has long been engaged in the research on the structure and function of the C group GPCR receptors.
Article link: https://elifesciences.
