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Recently, Biosensors & Bioelectronics, an authoritative academic journal in the field of biosensors, published a research paper on nucleic acid aptamer molecular design by Professor Huang Qiang's research group at the School of Life Sciences of Fudan University and the State Key Laboratory of Genetic Engineering: De novo design of DNA aptamers that target okadaic acid (OA) by docking-then-assembling of single nucleotides
Biosensors have the characteristics of high sensitivity, strong specificity, simple operation, etc.
In the study, Professor Huang Qiang's research group used computational structure biology technology and learned from the concept of drug molecular fragment design, innovatively proposed the nucleic acid aptamer design method of "single nucleotide docking and assembly", and successfully designed the high affinity and high specific nucleic acid aptamer of
Figure 1.
Song Menghua, a doctoral student in the School of Life Sciences, was the first author of the paper, Professor Huang Qiang was the corresponding author, and Li Yuanyuan, Dr.
The link to the paper is:
Release date: 8/9/2022
