Huang facan: create the largest base of biological enzyme products in China

Recently, the reputation of Dr Huang facan and his Fujian Huacan Biotechnology Co., Ltd is spreading from near to far The local people are proud that such a high-tech enterprise has been paid more and more attention to by the society in their hometown, especially moved by Dr Huang facan's return to his hometown for investment and business In 2002, Dr Huang facan returned to his hometown from the United States, founded Huacan company, and carried out the construction of tool enzyme production system So far, Huacan company has completed the pilot test of more than 50 kinds of commonly used tool enzymes, and carried out mass production, partially filling the domestic gap, ending the long history of China's tool enzyme dependence on foreign imports For this reason, the author went to Sanming City, Fujian Province, where Huacan company is located, and interviewed Dr Huang facan For the national interest Fujian Huacan Biotechnology Co., Ltd is a high-tech enterprise in Fujian Province It is mainly engaged in the R & D and production of various kinds of biological enzymes, including instrumental enzyme (reagent enzyme), pharmaceutical enzyme, food enzyme, feed enzyme and industrial enzyme Among them, the R & D and production of instrumental enzyme constitute the core of the enterprise, which is also a way that Dr Huang facan has devoted himself to research and cracking for more than ten years A scientific subject of great significance Dr Huang facan graduated from the Institute of genetics and developmental biology, Chinese Academy of Sciences, mainly engaged in the research of molecular genetics; in 2001, he graduated from the medical school of New York State University with a doctor's degree; in 2003, he completed his postdoctoral research in the medical school of the University of Pennsylvania Dr Huang facan told reporters that during his studies and postdoctoral work in the United States, his research topic was molecular biology of cardiovascular development, and the research on instrumental enzymes was an amateur "private activity" In the case of limited research conditions, Huang fancan finally separated 216 genes related to toolzymes through arduous efforts, and formed corresponding expression vectors and gene engineering strains Why does Dr Huang facan love instrumental enzymes? According to reports, toolase is a huge system composed of nearly 300 different enzymes, including restriction endonucleases, polymerases, DNA / RNA modifying enzymes and other proteases It is the most basic tool supporting the development of gene engineering products and molecular biology research in modern biotechnology industry Therefore, instrumental enzyme system is the core of modern biotechnology industry, which symbolizes the level and strength of the separation, purification and production of various high-purity enzymes in the field of biotechnology in a country, as well as the honor of a country At present, only NEB company, Promega company and MBI fermentas company of former Soviet Union have established two complete tool enzyme production systems in the world In addition, Takara company of Japan has basically established one production system At the same time, some research institutes in China have also done some separation and extraction of instrumental enzymes, but they are all for the purpose of scientific research and have not formed systematic and industrial production Therefore, at present, the tool enzymes produced by a few other countries are mainly sold in China Imperfection breeds struggle Thanks to China's long-term dependence on foreign imports, Dr Huang fancan hopes to establish a set of Chinese own toolenzyme production system to fulfill his responsibility for the honor of the country and share billions of dollars in the international market of toolenzymes Therefore, Dr Huang facan resolutely returned to his hometown Sanming City, Fujian Province in 2002 to establish Fujian Huacan Biotechnology Co., Ltd and carry out the construction of tool enzyme production system The prospect of industrialization of "enzyme" is limitless Dr Huang facan has a unique and profound understanding of the role and Prospect of toolzyme He vividly told reporters that the role of toolzyme in the biotechnology industry is just like the precision machine tools for manufacturing steel in automobiles and airplanes and the tools for manufacturing furniture, such as knives and saws Therefore, toolzyme system is an essential thing for the establishment of an independent biotechnology industry system in China Physical foundation is the most important tool to support the development of genetic engineering products and molecular biology research in modern biotechnology industry It has strong industrial relevance and affects the development of agriculture, medicine, military industry and other industries in China Thanks to the sense of urgency and importance of the development of China's tool enzyme industry, since the establishment of Huacan company in 2002, Dr Huang facan has devoted his financial and energy to promoting the research and development and industrialization of tool enzyme through various ways At present, Huacan company has invested more than 80 million yuan, acquired 118 mu of land, built production plant, GMP standard workshop and related laboratories with a total area of about 33000 square meters, with more than 320 production technicians, and has produced more than 170 kinds of related products It has preliminarily completed the supporting system for large-scale production of toolzyme, pharmaceutical enzyme, animal blood comprehensive utilization and fetal bovine serum, which is a tool in China The establishment of enzyme system laid a good foundation In 2006, the production value of the company has reached more than 24 million yuan The tool enzyme project researched and developed by the company has won the second prize of science and technology progress of Fujian Province It has been approved by the Ministry of science and technology of the people's Republic of China and listed as the key project of "biomedical key reagent" in the field of biological and pharmaceutical technology in the 863 plan of the people's Republic of China Its technical achievements have been appraised by the science and Technology Department of Fujian Province and have independent intellectual property rights The technology has reached the domestic advanced level in the aspects of high-efficiency expression of toolzyme, host fermentation, separation and extraction, and the construction of high-efficiency expression vector and affinity purification technology has reached the international advanced level In an interview with reporters, Dr Huang facan said that with the development and progress of science and technology, the biotechnology industry will get faster development, it will be a new bright spot of global economic development, and the demand for toolenzymes will also increase substantially Dr Huang fancan also confidently said that Huacan company focuses on the research and development of tool enzymes, mainly to break the monopoly of tool enzymes in foreign countries, so that the development of China's biotechnology industry is "not controlled by others", and to meet the growing demand for tool enzymes in the development of China's Biotechnology industry In addition, Huacan company has to enter the international market, compete with foreign companies, and share the fruits of economic globalization For the sake of national interests and the progress of national science and technology, as well as to realize the industrialization of all tool enzyme systems and enzyme preparations for other purposes, Huacan company has just established a production line in Fujian Province to process 1000 tons of animal blood annually, which can comprehensively utilize animal blood to produce thrombin, superoxide dismutase, peptone and other pharmaceutical raw materials In order to solve the problem of some raw materials for the production of instrumental enzymes, the company has also established a joint venture in Daying, Sichuan Province and Shijiazhuang, Hebei Province to produce raw materials and semi-finished products for animal organs, fetal cattle and newborn cattle serum, further improve the company's supply chain of production raw materials, give full play to the advantages of industrial clusters, promote the development of local agriculture, rural areas and farmers industries, and extend the animal husbandry industry chain Dr Huang told reporters that in the past, most animal blood was treated as waste products, which not only caused waste, but also polluted the environment Therefore, the development of Huacan company has also promoted the local related industries, especially the progress of agriculture and the development of circular economy At present, Huacan company also actively cooperates with relevant units in the research and development of protease; at the same time, in order to promote the application of instrumental enzymes, Huacan company also set up offices and product distribution centers in Beijing, Shanghai, Guangzhou, Fuzhou, Changchun, Chongqing, Hangzhou and other places to coordinate Market sales, forming a relatively complete marketing network It is pointed out in the special plan for the development of high and new technology industry in the Tenth Five Year Plan of China that "biotechnology industry engineering focuses on the development of medical and biological fields and agricultural biological fields" Toolzyme belongs to biotechnology products Its development can not only promote the development of enzyme preparation industry, but also promote the development of agricultural industry, extend the industrial chain of animal husbandry, promote the development of medicine industry and health industry, and ensure the independence of the development of biological warfare agents and genetic weapons in China                Dr Huang facan introduced that after the establishment of Huacan company, it has attracted the attention of all sectors of the society, and also received the strong support from leaders at all levels, departments and all aspects of the society The Ministry of science and technology of the people's Republic of China, Fujian Provincial Development and Reform Commission, economic and Trade Commission, Sanming municipal government, etc have all given financial support to Huacan company, and Datian county government has also given support in land and finance With the strong support of the government and all sectors of the society, Huacan company has gradually embarked on the right track At the same time, Dr Huang facan also said that at present, because most people don't know much about toolzyme, they don't know enough about its importance; and toolzyme is related to the development and national security of our whole country's biotechnology industry, and the industrialization of toolzyme is related to the major events of the whole country and the nation, with a very broad prospect Toolzyme is a huge system composed of nearly 300 different enzymes At present, there are more than 100 kinds of toolzyme in research and development and pilot production, which need a large amount of capital investment Therefore, Huacan company hopes to establish cooperation with relevant enterprises and investment institutions Huacan company will also provide biotechnology enterprises with the production technology of various enzymes for pharmaceutical raw materials As long as there is strong financial support, I China's tool enzyme industry will be bigger and stronger.