Hu Guohong's research group from the Institute of Nutrition and Health found a new mechanism for the regulation of breast cancer lung metastasis dormancy

On September 2, 2021, the international academic journal Nature Communications published an online report entitled "Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63" by Hu Guohong's research group at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences .

Breast cancer is one of the main threats to women's health.

Previous studies have noted that dormant tumor cells may have the growth arrest and pluripotency characteristics of normal stem cells

This study found that M-BCSC has a stronger ability to spread from the tumor in situ than E-BCSC, but E-BCSC that spreads to the lungs is more likely to quickly form metastases, while M-BCSC tends to Yu is dormant in the lungs

In summary, this study explains the functional mechanism of NR2F1-AS1 in the regulation of lung metastasis dormancy in breast cancer cells, and explains the role of CSCs in metastasis dormancy from the perspective of BCSCs heterogeneity, which is useful for our understanding of tumor cell metastasis Hibernation has important theoretical significance

Researcher Hu Guohong, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, is the corresponding author of the paper, and PhD student Liu Yingjie and postdoctoral fellow Zhang Peiyuan are the co-first authors

Article link: https:// NR2F1-AS1 through the NR2F1-ΔNp63 signaling pathway to regulate the molecular mechanism of breast cancer cell metastasis dormancy model diagram