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How to use pregabalin? These 5 points should be mastered

 Last Update: 2022-10-01
 Source: Internet
 Author: User

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Pregabalin, as a new type of drug for the treatment of neuropathic pain, has been widely used clinically for the treatment of postherpetic neuralgia, fibromyalgia, diabetic neuropathy and so on
.

In the United States, it has been approved by the U.
S.
Food and Drug Administration (FDA) for the treatment of postherpetic neuralgia, fibromyalgia, diabetic peripheral neuropathy, spinal cord injury-related neuralgia, and partial seizures
in select adults with epilepsy.

Second, the mechanism of action of neuropathological pain is related
to the calcium ion channel changes of the nervous system.

Pregabalin, which binds to the α_2-δ subunit of calcium channels in the nervous system, inhibits the inflow of^Ca2+ in the presynaptic membrane of neurons, reduces the release of excitatory neurotransmitters (glutamic acid, substance P, calcitonin gene-related peptides), and thus controls pain
.

Third, the dosage

Pregabalin that has been marketed in China includes oral regular-release preparations and sustained-release preparations
.

Oral regular-release preparations: including pregabalin capsules, pregabalin oral solution, 2 to 3 times a day, can be taken with food, can also be taken alone, the specific dosage is shown in the table below
.

Oral extended-release preparations: pregabalin extended-release tablets once daily after dinner
.

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