-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
*For medical professionals only
Dopasazide tablets cannot be taken at the same time as meals, but should be taken 1 hour before meals or 1.
5 hours after meals, and doctors will explain this when prescribing dopaserazide tablets in the outpatient clinic
.
Why is this emphasized? The author summarizes the principle of dopaserazide tablets for your reference
.
We all know that Parkinson's disease is closely related to the deficiency of dopamine neurotransmitters in the basal ganglia of the brain, but if taken directly, dopamine has no way to enter the brain, because there is a very strong blood-brain barrier like a wall
.
Levodopa, on the other hand, has the ability to cross the city wall and enter the brain where it can be metabolized into dopamine to play a role, so it plays an important role
in the treatment of Parkinson's disease.
Medical research on the pathological mechanism of Parkinson's disease suggests that the occurrence of Parkinson's disease is closely related to the place called substantia nigra in the brain, and the dopaminergic neurons in this part of Parkinson's disease will degenerate and die for a variety of reasons, resulting in a significant decrease
in dopamine in the brain compared with normal people.
As a neurotransmitter in the brain, a significant decline in dopamine can cause patients to have motor symptoms
of Parkinson's disease.
How do you eat dopasrazine tablets? Depending on the individual patient, the amount of dopazine tablets can vary
throughout the day.
Also, the time of taking the medicine should be separated from the eating time, and try to take the medicine
1 hour before the meal.
The drug metabolism of dopasazide tablets is relatively fast, and the duration of the efficacy is relatively short
.
In patients in the honeymoon phase of the drug, small doses of dopaserazide tablets taken orally 2-3 times a day may control symptoms
very stably.
Patients with early stage of the disease can start with 1/4-1/2 tablets at a time, 2-3 times
a day.
However, due to individual differences, there is no unified standard, and it should be taken
according to the doctor's advice.
For patients with intermediate and advanced stages, the effect of dopasazide tablets is maintained for a short time, and the number of doses can be increased to more than
4 times / day.
But again, please take the medicine
as directed by your doctor.
Cases of more than 5 tablets/day are rarely reported, and if this dose is reached, surgery can be considered
.
Is it possible to simply take dopamine orally to supplement the missing dopamine in the brain? Nope
.
Because there is a barrier between the peripheral blood circulation system and the central nervous system, including the brain, which is medically known as the blood-brain barrier, it will strictly control the blood-brain transport of substances, and the ability of oral absorption of dopamine into the blood into the brain through this barrier is very limited
.
As a precursor of dopamine, levodopa can pass through the blood-brain barrier and decarboxylate into dopamine in the brain to exert pharmacological effects, which also makes it one of the most important drugs in the treatment of
Parkinson's disease.
However, not only the dopa decarboxylase that can decarboxylate levodopa exists in the brain, but also other tissues, so the oral part of L-Dopa will be decarboxylated outside the brain, reducing the dopamine that finally reaches the brain, and even has certain side effects
.
Another ingredient in dopaserazide tablets, benserazine, is a peripheral dopa decarboxylase inhibitor, which can reduce the decarboxylation of levodopa outside the brain, thereby increasing the utilization rate
of levodopa.
What is the basis for taking 1 hour before or 1.
5 hours after meals? Studies have shown that levodopa competes with neutral amino acids
, especially intestinal absorption and blood-brain barrier transport.
After eating foods containing high protein, the concentration of neutral amino acids in the plasma is increased, which will interfere with the transport of levodopa into the brain, thereby reducing the efficacy
of levodopa.
Therefore, it is recommended that dopazine tablets be taken at least 1 hour before or 1.
5 hours after meals to achieve the best effect
.
Foods containing protein components (milk, meat, tofu, etc.
) have a certain effect on the efficacy of dopasazine tablets, so it is necessary to take the medicine
at a long interval with the above foods.
What is the best dose to take one tablet of dopaserazide = 250mg? According to the 2020 edition of the Chinese guidelines for the diagnosis and treatment of mild cognitive impairment in Parkinson's disease [3], the initial dosage of dopa serazid tablets is recommended to be 62.
5mg (1/4 tablet) -125mg (1/2 tablet) each time, 2-3 times / day, and the dose is adjusted according to the improvement of symptoms If the efficacy does not control the symptoms well, combination therapy
can also be initiated.
Available evidence suggests that early administration of small doses (≤400 mg/day) does not increase the incidence
of dyskinesia later in Parkinson's disease.
Side effects
of dopazazine tablets 1, gastrointestinal reactions: During the initial treatment of dopaserazide tablets, many patients will have gastrointestinal symptoms such as nausea, vomiting, diarrhea, etc.
, which can be basically controlled
by taking it with drinks or slowly increasing the dose.
2.
Psychiatric symptoms: Patients receiving dopasazine tablets may be depressed, but this may also be a clinical manifestation
of Parkinson's disease and restless legs syndrome.
Agitation, anxiety, insomnia, hallucinations, delusions, and transient disorientation
may occur in older patients or those with a similar history.
3.
Nervous system: individual cases have been reported with taste loss or taste disorders
.
Movement disorders (dyskinesia) may develop later in treatment, and reducing the dose usually eliminates symptoms or tolerates
them.
With the prolongation of treatment time, there may also be fluctuations in treatment response, including: freezing attacks, deterioration of the end of the dose, and "on-off" phenomenon
.
4.
Other incidental phenomena: occasional reports of anorexia; Occasionally arrhythmia; Occasionally orthostatic hypotension, etc
.
Resources:
Where can I see more about neurological medicine beds?
Come to the "Doctor Station" and take a look 👇
To know what is it is more important to know why it is
Dopasazide tablets cannot be taken at the same time as meals, but should be taken 1 hour before meals or 1.
5 hours after meals, and doctors will explain this when prescribing dopaserazide tablets in the outpatient clinic
.
Why is this emphasized? The author summarizes the principle of dopaserazide tablets for your reference
.
We all know that Parkinson's disease is closely related to the deficiency of dopamine neurotransmitters in the basal ganglia of the brain, but if taken directly, dopamine has no way to enter the brain, because there is a very strong blood-brain barrier like a wall
.
Levodopa, on the other hand, has the ability to cross the city wall and enter the brain where it can be metabolized into dopamine to play a role, so it plays an important role
in the treatment of Parkinson's disease.
Medical research on the pathological mechanism of Parkinson's disease suggests that the occurrence of Parkinson's disease is closely related to the place called substantia nigra in the brain, and the dopaminergic neurons in this part of Parkinson's disease will degenerate and die for a variety of reasons, resulting in a significant decrease
in dopamine in the brain compared with normal people.
As a neurotransmitter in the brain, a significant decline in dopamine can cause patients to have motor symptoms
of Parkinson's disease.
How do you eat dopasrazine tablets? Depending on the individual patient, the amount of dopazine tablets can vary
throughout the day.
Also, the time of taking the medicine should be separated from the eating time, and try to take the medicine
1 hour before the meal.
The drug metabolism of dopasazide tablets is relatively fast, and the duration of the efficacy is relatively short
.
In patients in the honeymoon phase of the drug, small doses of dopaserazide tablets taken orally 2-3 times a day may control symptoms
very stably.
Patients with early stage of the disease can start with 1/4-1/2 tablets at a time, 2-3 times
a day.
However, due to individual differences, there is no unified standard, and it should be taken
according to the doctor's advice.
For patients with intermediate and advanced stages, the effect of dopasazide tablets is maintained for a short time, and the number of doses can be increased to more than
4 times / day.
But again, please take the medicine
as directed by your doctor.
Cases of more than 5 tablets/day are rarely reported, and if this dose is reached, surgery can be considered
.
Is it possible to simply take dopamine orally to supplement the missing dopamine in the brain? Nope
.
Because there is a barrier between the peripheral blood circulation system and the central nervous system, including the brain, which is medically known as the blood-brain barrier, it will strictly control the blood-brain transport of substances, and the ability of oral absorption of dopamine into the blood into the brain through this barrier is very limited
.
As a precursor of dopamine, levodopa can pass through the blood-brain barrier and decarboxylate into dopamine in the brain to exert pharmacological effects, which also makes it one of the most important drugs in the treatment of
Parkinson's disease.
However, not only the dopa decarboxylase that can decarboxylate levodopa exists in the brain, but also other tissues, so the oral part of L-Dopa will be decarboxylated outside the brain, reducing the dopamine that finally reaches the brain, and even has certain side effects
.
Another ingredient in dopaserazide tablets, benserazine, is a peripheral dopa decarboxylase inhibitor, which can reduce the decarboxylation of levodopa outside the brain, thereby increasing the utilization rate
of levodopa.
What is the basis for taking 1 hour before or 1.
5 hours after meals? Studies have shown that levodopa competes with neutral amino acids
, especially intestinal absorption and blood-brain barrier transport.
After eating foods containing high protein, the concentration of neutral amino acids in the plasma is increased, which will interfere with the transport of levodopa into the brain, thereby reducing the efficacy
of levodopa.
Therefore, it is recommended that dopazine tablets be taken at least 1 hour before or 1.
5 hours after meals to achieve the best effect
.
Foods containing protein components (milk, meat, tofu, etc.
) have a certain effect on the efficacy of dopasazine tablets, so it is necessary to take the medicine
at a long interval with the above foods.
What is the best dose to take one tablet of dopaserazide = 250mg? According to the 2020 edition of the Chinese guidelines for the diagnosis and treatment of mild cognitive impairment in Parkinson's disease [3], the initial dosage of dopa serazid tablets is recommended to be 62.
5mg (1/4 tablet) -125mg (1/2 tablet) each time, 2-3 times / day, and the dose is adjusted according to the improvement of symptoms If the efficacy does not control the symptoms well, combination therapy
can also be initiated.
Available evidence suggests that early administration of small doses (≤400 mg/day) does not increase the incidence
of dyskinesia later in Parkinson's disease.
Side effects
of dopazazine tablets 1, gastrointestinal reactions: During the initial treatment of dopaserazide tablets, many patients will have gastrointestinal symptoms such as nausea, vomiting, diarrhea, etc.
, which can be basically controlled
by taking it with drinks or slowly increasing the dose.
2.
Psychiatric symptoms: Patients receiving dopasazine tablets may be depressed, but this may also be a clinical manifestation
of Parkinson's disease and restless legs syndrome.
Agitation, anxiety, insomnia, hallucinations, delusions, and transient disorientation
may occur in older patients or those with a similar history.
3.
Nervous system: individual cases have been reported with taste loss or taste disorders
.
Movement disorders (dyskinesia) may develop later in treatment, and reducing the dose usually eliminates symptoms or tolerates
them.
With the prolongation of treatment time, there may also be fluctuations in treatment response, including: freezing attacks, deterioration of the end of the dose, and "on-off" phenomenon
.
4.
Other incidental phenomena: occasional reports of anorexia; Occasionally arrhythmia; Occasionally orthostatic hypotension, etc
.
Finally, remind colleagues that in the treatment of Parkinson's disease, it is necessary to tell patients the importance of taking drugs correctly and regularly, and improve patients' medication compliance, which is the premise
of achieving good treatment results.
Of course, with the prolongation of time, the efficacy of the drug decreases, the dose needs to be adjusted accordingly, and the patient should be told to carry out under the guidance of a doctor, and it is not appropriate to adjust
it without authorization.
Resources:
[1] Qu Xinhui.
How Parkinson's patients take dopasazine tablets.
Old Friends, 2022, (06).
[2] HU Xiaowu, LI Rui, WANG Han, et al.
Guidelines for the use of "dopa" in Parkinson's patients.
Family Medicine, 2015, (09).
[3] WANG Lijuan,FENG Shujun,NIE Kun.
Guidelines for the diagnosis and treatment of mild cognitive impairment in Parkinson's disease in China (2020 edition).
Chinese Journal of Neuropsychiatric Diseases.
2021,47(01).
Where can I see more about neurological medicine beds?
Come to the "Doctor Station" and take a look 👇
