How to troubleshoot drug stability test chambers?

Drug stability test chamber is a kind of equipment used by most enterprises and high efficiency, especially for pharmaceutical companies
.
We want to troubleshoot the common problems of drug stability test chambers, first of all, we need to understand the meaning and technical principle and operation process of drug stability test chambers, on this basis, we can understand the possible failures of drug stability test chambers, and then understand simple self-troubleshooting
.
1.
What is a drug stability test chamber? Stability test chambers are used for intensive research
in the pharmaceutical, medical, biotechnology and all related industries, including life sciences.
GMP principle requirements 25°C/60%RH humidity long-term stability test conditions
.
In the accelerated test 40°C/75%RH humidity test standard for 6 months, is the pharmaceutical industry stability test system field, mainly simulating the environmental climate in temperature, humidity, light test
。 Second, what is the technical principle of the drug stability test chamber? Technical principle: (1) control principle: temperature and humidity sensor will pass the current temperature and humidity value to the controller, the controller according to the current operating state, the temperature value and humidity value and the set value are compared, PID calculation, determine the heating and humidification output power size, by controlling the solid state relay, control the heating and humidification connection time, that is, the controller in the time of the turn-on percentage
.
By continuously adjusting the heating and humidification output, the temperature and humidity are relatively stable
.
(2) Refrigeration and dehumidification principle: the compressor compresses the refrigerant (R134a) into high temperature and high pressure gas, condenses into a room temperature and high pressure liquid through the condenser, sprays into the evaporator through the throttling device for gasification, and the refrigerant gasifies a large amount of heat absorbing, so that the temperature of the evaporator is reduced, and the evaporator absorbs the air heat flowing through the evaporator and liquefies the water vapor in the air, so that the air temperature drops and the humidity decreases
.
The low-temperature, low-pressure gas is sucked back into the compressor and so on
.
Third, the common fault problems and solutions of drug stability test chambers? 1.
The reason why the power indicator is not lit: (1) The socket has no power supply (2) The fuse is fused solution: (1) Check the socket (2) Change the fuse 2.
The temperature is set to 68 °C (or greater than 68 °C), the alarm stops, and the temperature drops to the indoor temperature after the reason: ultra-high temperature protection action (factory-designed protection function, and very faulty
。 If there are special requirements, first explain when ordering) Solution: the temperature setpoint should be less than 68°C 3.
The reason why the temperature window display value deviates too much from the actual value: check whether the temperature correction value SC1 is correct Solution: the normal state of the new machine SC1=0 (-0.
5~0.
5) 4.
The compressor is refrigerating, but the temperature cannot be lowered, and the reason for the large temperature difference between the upper and lower layers: the refrigeration indicator is on, the compressor is refrigerating, the temperature cannot be lowered, check whether the things on the bracket are stacked too full, It blocks the circulating wind
that moves up and down.
Solution: Remove the overly full culture on each layer, leaving one-third to half of the air duct in each layer 5.
Reasons for not heating (not heating up): (1) The heating indicator light does not light up for the control board failure (2) The heating indicator light is on for the heating tube to be burned Solution: (1) Change the control board (2) Change the heating tube 6.
The reason for not cooling (not cooling): (1) The refrigeration indicator does not light up for the control board failure (2) The refrigeration indicator light is on for the refrigeration system failure (3) The compressor starts or runs again (4) The delay time has not arrived Solution: (1) Change the controller (2) Repair the refrigeration system (3) Please wait for a while 7.
Heating or cooling indicator light is on but does not heat up or does not cool down Reason: refrigeration system failure or heating tube bad solution: repair refrigeration system failure or change heating tube is bad 8, no humidification (the display humidification indicator is on, but the humidifier indicator is not on) Reason: (1) The humidifier power switch is not turned on (2) Humidifier fault solution: (1) Turn on the humidifier power switch (2) Change the humidifier 9.
The humidification indicator on the test chamber is on, sending out a humidification signal, but the humidifier is not humidified
。 Reasons: (1) Lack of water in the humidifier (2) The water in the tank is not put well; (3) Circuit board or humidifier fault solution: (1) Fill the water tank with water (2) Please put the water tank
firmly on the right position.
(3) Replace the circuit board or humidifier failure 10.
The humidity does not reach the set value (the humidification indicator on the display screen on the incubator is on, and the humidifier indicator is also green) Reasons: (1) The humidifier is not turned on or the amount of fog out of the humidification is adjusted too small (2) The temperature setting value is too low, and it is difficult to achieve
low temperature and high humidity 。 (3) Most of the solutions to the humidifier base water: (1) increase the humidity and fog output a little larger (2) adjust the temperature setpoint a little higher or customize non-standard products (3) Drain the base water part 11.
Causes of humidity overshoot: If the humidity is set to 60%, the humidity arrives, stop humidification, but the overshoot to 68% humidity to the set value, the humidifier still keeps humidifying the humidity outside, and the door is not closed Solution: (1) Properly close the small humidity and fog volume (2) The circuit board is faulty (3) Close the door 12.
The reason why the printer does not print: (1) The printer does not have a power indication (2) Communication line is broken (3) Incorrect automatic printing parameter setting solution: (1) Replace the printer power supply (2) Connect the communication line (3) The parameter Cn=1 will be automatically printed 13.
The buzzer sounds, the power indicator flashes Reason: the power supply voltage is unstable Solution: check the power supply line, improve the power supply of the grid, or increase the stable power supply 14.
The buzzer sounds, and the temperature exceeds the set value±4 °C Reason: (1) The test chamber door is not closed properly (2) Refrigerant leakage (3) The circulating fan does not rotate (4) Control board fault solution: (1) Close the door, Power on again after 2 minutes of power failure (2) Leak detection, repair welding, recharge refrigerant (3) Replace the circulating fan (4) Replace the control board