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Pharmaceutical Network Technical Article : It is learned that there are pharmaceutical companies in the production of capsules in the process, because of the fine powder, the machine filling will produce appearance defects, has been through artificial "picking drugs" to remove The technical staff of the pharmaceutical company to carry out research, through the capsule filling equipment continuous optimization and continuous debugging, the appearance of defective product rate reduced, but also greatly reduced labor costs
Industry pointed out that the filling quality of capsule fillers is very important, with the industry's strict regulation, which has become a very important concern of pharmaceutical companies, so the capsule filler equipment needs to continuously improve equipment, optimize the equipment structure, to help pharmaceutical companies better production
"In addition to the quality of the equipment itself, the equipment environment, the transportation process, and each station will have an impact on the filling quality "There are filler factory technicians said that users need to pay special attention to the equipment when operating several stations, including the following sections
First, the capsule turned and separated the station This station is a capsule feeding and separation mechanism, the purpose is to feed the capsule into the module and separate the sac, cap for the next step of the drug filling
The common problems of the station include poor separation, flycap, etc , technical staff reminded that the pressure adjustment for vacuum separation should be appropriate, not too large or too small, too small will make the phenomenon of separation of undesirable, at the same time, capsules must be purchased from regular manufacturers, and qualified by inspection
Second, fill the station This station mainly controls the filling weight of the capsule contents, and the main common problem is the instability of the filling contentweight
The reasons mainly include three aspects: First, the metering disk and the next module is not good, so that some of the finished capsule weight is always light Technicians pointed out that the problem here is not easy to find, the user assembly before production, debugging equipment here must do a good job, the second is the metering disk above the isolation block and the metering disk gap is too large, so that the drug through the gap into the metering hole caused the weight of the capsule is too large It is reported that the general isolation block and metering disk gap adjustment to 0.05 to 0.1mm as good, if too small will produce wear on the metering disk, damage equipment
In addition, the height of the powder on the metering disk also has a certain impact on the filling weight, the height of the powder is too low, will make the powder can not be timely into the metering hole caused by the capsule light, the height is too high will make the drug into the metering disk too much, the weight of the capsule is heavy
Third, waste capsules reject the station The function of this station is to discharge the poorly separated capsules in the above-mentioned station Technicians said that the key here is the size of the vacuum negative pressure, both to ensure that the unseparated capsules can be eliminated, but also can not be sucked out of the upper module cap Vacuum too small bad capsulecane can not be completely eliminated;
Four, the capsule lock the joint station This station is the capsule filled for the capsule, the capsule cap of the fit, is an important step in the capsule filling
Common problems of the station include: capsule insertion, the main reason is that the upper and lower moduleis is not good, the capsule in the lock-up of the sac, the cap is not on the same center line, resulting in damage to the sac or cap; The cause of the damage to the head and capsule is mainly due to the short locking length, the sac and the cap separation is due to the long lock ingesting caused the capsule not to lock, in the capsule transport process occurred cystic cap separation
Technical staff suggested that the user in the pre-production commissioning equipment to the capsule lock-in length measurement, to ensure that it is within the qualified range, so as to ensure the capsule filler stable production, to ensure the quality of the filling.