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Dietary vitamin A becomes retinol, which is internalized by LRP1 into cells to promote adaptive immunity in the intestine
Immunologists and geneticists at the University of Texas Southwestern Medical Center discovered how vitamin A enters the immune cells of the intestine.
"Now that we have more understanding of this important aspect of immune function, we may eventually be able to manipulate how vitamin A is delivered to the immune system to treat or prevent disease," Howard Hughes Medical Institute researcher, De Kesa Said Dr.
Dr.
Dr.
The lead author, Dr.
LRP1 was discovered more than 30 years ago by Joachim Herz, MD, a researcher in southwestern Utah, who is the director of the Center for Translational Neurodegeneration and a professor of molecular genetics, neurology and neuroscience
Dr.
The research results published in "Science" show that LRP1 is the carrier of retinol into myeloid cells
