How many of the "high-risk behaviors" that make the onset of colorectal cancer younger?

In the past few decades, the incidence of early-onset colorectal cancer (CRC; younger than 50 years) has been on the rise

In the past few decades, the incidence of early-onset colorectal cancer (CRC; younger than 50 years) has been on the rise

Although genetic factors are important in early-onset CRC, the body composition, diet, life>

Although genetic factors are important in early-onset CRC, the body composition, diet, life>

However, a comprehensive, large-scale assessment has not been conducted to compare these risks with the risks of late-onset CRC (50 years and older) and to assess whether the risk of early-onset CRC is related to specific CRC anatomical subsites

This study aims to determine whether the risk factors associated with late-onset CRC are also related to early-onset CRC

1.

1.

The reference ages of the early-onset CRC cases and the control group were similar (45.

In the multivariate model, early-onset CRC and irregular use of non-steroidal anti-inflammatory drugs (OR ¼1.

In the multivariate model, early-onset CRC and irregular use of non-steroidal anti-inflammatory drugs (OR ¼1.

2.

2.

By assessing the risk of early-onset CRC by cancer sub-sites (Table 3), it can be found that irregular use of non-steroidal anti-inflammatory drugs, more red meat intake, lower dietary fiber intake, and lower folic acid intake Intake, lower calcium intake, abstinence and heavy drinking ( > 28g/day), > lower education level are all related to the high risk of early-onset CRC of the rectum and colon

In summary, this study included 3767 cases of early-onset colorectal cancer and 4,049 cases of control group.

In summary , this study included 3767 cases of early-onset colorectal cancer and 4049 cases of control group.

It is worth noting that this study also statistically examined how the association between risk factors and early colorectal cancer differs according to the anatomical location- compared with the colon, non-steroidal anti-inflammatory drugs are used irregularly and at lower levels.
Dietary fiber intake and lower folic acid intake may be more closely related to early-onset rectal cancer
.
This study is also the first to comprehensively evaluate the relationship of mature CRC risk factors in the development of early-onset colorectal cancer
.
It is also the first study to comprehensively evaluate the relationship of mature CRC risk factors in the development of early-onset colorectal cancer
.

In general, this study found that a group of non-genetic risk factors for late-onset CRC also have additional correlations with early-onset CRC
.
Our study also provides the first evidence linking risk factors for early-onset CRC with anatomical subsites, especially low dietary fiber intake
.
These results provide key insights into the risk factors that lead to CRC manifestations in young individuals, and provide a basis for identifying those most at risk, which are critical to reducing the growing medical economic burden of this disease
.

In general, this study found that a group of non-genetic risk factors for late-onset CRC also have additional correlations with early-onset CRC
.
Our study also provides the first evidence linking risk factors for early-onset CRC with anatomical subsites, especially low dietary fiber intake
.
These results provide key insights into the risk factors that lead to CRC manifestations in young individuals, and provide a basis for identifying those most at risk, which are critical to reducing the growing medical economic burden of this disease
.
This is essential to alleviate the increasing medical economic burden of this disease
.

 

Original source:

Alexi N.
Archambault, et al.
Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer.
JNCI Cancer Spectrum, 2021, Vol.
5, No.
3.

Alexi N.
Archambault, et al.
Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer.
JNCI Cancer Spectrum, 2021, Vol.
5, No.
3.

doi: 10.
1093/jncics/pkab029.

doi: 10.
1093/jncics/pkab029.


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