How magical is the magic medicine! Discover the mysterious therapeutic effect of aspirin!

When it comes to aspirin, we all know that it is a kind of antipyretic and analgesic drug However, in recent years, with the in-depth research of scientists, they began to find that aspirin has many important uses In this paper, the editor will sort out the relevant research results and share them with you! Photo source: medicaexpress.com! Low dose aspirin may be effective in the treatment of head and neck cancer and lung cancer! Can aspirin help tuckle some cancers? Recently, at the American Conference on radiation oncology held in Chicago, scientists from Roswell Park Comprehensive Cancer Research Center and other institutions found that low-dose aspirin could improve the survival rate of patients with head and neck cancer and lung cancer through two studies In the first study, the researchers reviewed data from 460 patients with head and neck squamous cell carcinoma (HNSCC) or early non-small cell lung cancer (NSCLC) The researchers found that the consumption of non steroidal anti-inflammatory drugs (such as low-dose aspirin), together with standard radiotherapy or chemotherapy, could increase the survival rate of these cancer patients by 8% In the second study, the researchers studied 164 NSCLC patients who received precise, high-dose radiotherapy, 57% of whom received aspirin and achieved 2-year survival (compared with 48% of the other patients) Dr Austin Iovoli, the researcher, said: 'we are particularly interested in the longer survival of these patients, although anti-inflammatory drugs seem to have little effect on the effectiveness of cancer treatment 【2】 Cancer: the magic medicine will come back! Aspirin may interact with DNA methylation of cells to change the prognosis of breast cancer patients! Doi: 10.1002/cncr.32364 recently, in a research report published in the international journal Cancer, scientists from the University of North Carolina found that if they were diagnosed Women with specific DNA features in specific regions of the genome may survive longer if they take aspirin before breast cancer This study suggests that later researchers may need to further study the potential of aspirin in the prevention or treatment of breast cancer patients At present, researchers don't know why some patients benefit from special therapy, while others do not In some cases, genes may play a key role, while in other cases, chemical modification of DNA may also be crucial Chemical modification of DNA is also known as epigenetic modification, which includes DNA methylation According to researcher Tengteng Wang, we want to determine whether DNA methylation will affect the effect of aspirin in breast cancer patients In this article, we will study the effect of aspirin on breast cancer DNA methylation in tissues and circulating cells in patients' blood was analyzed, including DNA sites that control the expression of 13 breast cancer-related genes In this study, the researchers analyzed for the first time the effect of DNA methylation on the association between aspirin use and death in breast cancer patients 【3】 J affect dis: aspirin works again! Hope to treat drug-resistant tuberculosis! Doi: 10.1093/infdis/jiz110 recently, an international magazine was published in the Journal of infection In the Research Report on diseases, scientists from Sydney Sydney Century Research Institute revealed a new type of target for the treatment of drug-resistant tuberculosis In this paper, the researchers found that Mycobacterium tuberculosis can intercept platelets in the coagulation system to weaken the function of the immune system Today, we have not effectively eradicated tuberculosis globally Every year, more than 1400 people are infected in Australia alone Drug-resistant tuberculosis is particularly fatal and expensive to treat It costs 250000 Australian dollars to treat a patient in Australia Researchers have always wanted to treat tuberculosis by increasing the effectiveness of the immune system Using the zebrafish model of tuberculosis, researchers can observe the accumulation of blood clots and the activation of platelets in the infected area through a fluorescence microscope Dr Stefan oehlers said that observing the changes of cells in zebrafish in real time can help to understand the progress of the disease 【4】 Cost: taking low-dose aspirin every day can relieve COPD! Doi: 10.1016/j.best.2018.11.028 many Americans take low-dose aspirin every day to protect their hearts, but now a study shows that aspirin also seems to prevent chronic obstructive pulmonary disease (COPD In a study of patients with COPD, the researchers found that aspirin was related to the reduction of moderate deterioration of COPD, but not serious deterioration Aspirin can also reduce the attack of moderate to severe dyspnea "This study shows that adding aspirin to existing treatment regimens may improve the health of patients." Ashraf fawzy, a lung and critical care researcher at Johns Hopkins University, said, but said more research was needed to confirm Fawzy and his colleagues looked at nearly 1700 COPD patients, funded by NIH in the United States About 45% of patients reported that they regularly took low-dose aspirin (81 mg) at the beginning of the study 【5】 Cell: aspirin is expected to treat a class of autoimmune diseases, cyclic guanosine synthetase (CGAs) as a DNA receptor Since it was discovered by Chen Zhijian, a Chinese scientist who won the "scientific breakthrough Award", it has become an important scientific subject that scientists in the field of life science are keen to pursue in recent years Using aspirin, which has been used for more than one hundred years, Zhang Xuemin's team and Dr Li Tao's team from the Military Medical Research Institute of the PLA Academy of Military Sciences revealed their role in controlling the activation of CGAs through acetylation mechanism The research results were published online in the early morning of February 22 in the journal Cell "Because DNA receptor CGAs proteins play a key role in DNA triggering immune and autoimmune responses from within cells." At the media Symposium of the Academy of Military Sciences held on the same day, the research team described to reporters the significance and experience of carrying out relevant research "The important role of CGAs in the occurrence and treatment of diseases is similar to the cell's' Guardian ', which is very sensitive to external invaders Its intervention is a hot competition direction in the international frontier field Many international pharmaceutical groups and research teams are trying to find the intervention method of CGAs " Zhang added Photo source: cc0 public domain [6] SCI signal: Shenyao Zaiwei! Low dose aspirin may be effective against multiple sclerosis! Doi: 10.1126/scientific.aar8278 recently, in a research report published in the international journal Science Signaling, scientists from the Lenox Mountain hospital in Manhattan found that low-dose aspirin may help effectively resist the occurrence of multiple sclerosis by studying mice Although the current research is carried out in mice, the researchers believe that the results of this study are expected to be transformed into human clinical trials later Multiple sclerosis (MS) is an autoimmune disease, in which abnormal immune T cells attack and destroy the protective myelin protein on the surface of nerve cells Now there are more than 2.3 million people with multiple sclerosis around the world, said asaff Harel, a researcher Previous studies have shown that aspirin can effectively improve the weakness and other symptoms of patients with multiple sclerosis 【7】 JAMA Oncol: taking low-dose aspirin may reduce the risk of ovarian cancer doi: 10.1001/jamaoncol.2018.4149 in American women, ovarian cancer is the fifth most common cause of cancer-related death There is increasing evidence that inflammation plays a role in the development of ovarian cancer, and it has been noted that local inflammation during ovulation may be a driving factor Some analysts say aspirin reduces the risk of ovarian cancer by reducing inflammation Although previous studies have attempted to determine whether aspirin and other common anti-inflammatory drugs affect the risk of ovarian cancer, their results are inconsistent In a new study, researchers from Harvard's Chen Zengxi School of public health, Brigham women's Hospital and Moffett Cancer Research Center analyzed data from 205498 women who were part of the nurses' Health Study (NHS) and nurses' Health Study II Of these women, 1054 had ovarian cancer They studied women taking standard aspirin, low-dose aspirin, non steroidal anti-inflammatory drug (NSAID) and paracetamol, as well as information about the number of tablets taken, frequency of use, duration of use and duration of use The results were published in JAMA Oncology journal [8] JAMA Oncol: regular aspirin intake can reduce the risk of liver cancer doi:10.1001/jamaoncol.2018.4154 although hepatocellular carcinoma (HCC) is relatively rare, its incidence rate in the United States has increased over the past 40 years, and its mortality rate has increased faster than any other cancer HCC is the first cause of cancer death in the world The main risk factor for HCC is cirrhosis Cirrhosis can be caused by hepatitis B virus (HBV) or hepatitis C virus (HCV), alcohol use disorders, or nonalcoholic fatty liver disease HCC is usually diagnosed late, leading to an average survival of less than a year Aspirin is known to block the production of inflammatory lipids that can lead to liver damage, and although previous studies have suggested that regular aspirin use may help prevent HCC, information about its optimal dose and the required duration of treatment is still unknown In a new study, researchers from the U.S., China, Sweden and Singapore suggest that their findings support the conclusion from previous studies that regular aspirin use reduces the risk of HCC Their report analyzed data from two long-term epidemiological studies (NHS and HPFS as mentioned below) and found that regular aspirin use - two or more 325 mg aspirin tablets per week over a period of 5 years or more - resulted in a significant reduction in the risk of HCC, the results of which are published in the journal JAMA oncology 【9】 JCR and jiaidss: magic medicine shows its power again! Low dose aspirin can effectively inhibit HIV infection and transmission! Doi: 10.1016/j.jconrel.2018.03.010 doi: 10.1002/jia2.25150 recently, scientists from the University of Manitoba and other institutions in Canada found that low-dose aspirin may be expected to inhibit the spread of HIV, relevant research published in the International Journal of controlled release and Journal of the International AIDS Society HIV infection rates are still high in the population, especially among young African women In this study, researchers tested the effect of acetylsalicylic acid (ASA or aspirin) and other anti-inflammatory drugs on HIV targeted cells by conducting a joint study on a group of women with low risk of HIV from Kenya The preliminary results, published in the Journal of the International AIDS Society, are based on the role of inflammation in HIV transmission