How does the rise of the SARS-CoV-2 monogene cause cytokine storms?

, July 2, 2020 /PRNewswire/ -- Changes
in gene expression suggest that possible therapies for the prevention and treatment of COVID-19 are based on a combination of dexamethasone, ostrichol (vitamin D) and progenitor (vitamin E), thus destroying the "vicious circle" of COVID-19 inflammation
the INITIAL limited invasive ability of THE SARS-CoV-2 virus to attack only onegenetic target in the cell.comHowever, it leads to a wide range of different clinical symptoms, suggesting a variety of pathogenic mechanismsIn Restorative Neurology and Neuroscience, the researchers describe the process by which AhR is overactivated through the IDO1-canine-AhR signaling pathway, leading to "systemic AhR activation syndrome" (SAAS)The authors also hypothesized that treatment for the AhRs and IDO1 genes should reduce the severity of the infectionSAAS is the basis for inflammation, thromboembolism and fibrosis that can lead to severe coVID-19 disease and deathWhen a coronavirus (CoV) infection persists, it activates IDO1 by releasing cytokines in large quantitiesThis, in turn, perpetuates AhRs, which is already widespread, and the host immune response's self-limiting control mechanism sits off, triggering cytokine storms and causing the most severe symptoms of COVID-19"The SARS-CoV-2 virus is a living example of the virus being simply complicated by extremely complex targets," explained lead author DrWaldemar ATurski of the Department of Experimental and Clinical Pharmacology at the Medical University of Lublin, PolandDirect activation of CoVs to AhRs can lead to different episotype images, depending on the time of infection, overall health, hormone balance, age, gender, co-disease, but also the dietary and environmental factors that regulate AhRspicture source: IOS Press
author proves that CoV is the perfect virus, withno-no chance, and shows how difficult it is to stop them after a cell invasion They describe many of the characteristics and symptoms of COVID-19 that may depend on the activation of AhR, including thromboembolism, fibrosis, multiple organ damage, and brain damage They also explored how environmental factors, such as urban dust and diesel fumes, activate AhRs and make humans more susceptible to pathogens, including coronaviruses Physical exercise has a positive effect on IDO1 function and the reduction of AhRs the researchers hypothesized that when AhR is active and clinical symptoms are mild, the exclusion of known factors that increase AhR activation or the implementation of known factors that inhibit AhR activation should reduce the severity of the infection When the disease is fully diagnosed and the symptoms are severe, IDO1 is considered to be continuously activated, except for The CoV activation of AhRs Only the simultaneous downgrade of AhR and IDO1 can effectively break this vicious circle However, there are currently no licensed drugs that can reduce the activity of both AhR and IDO1 co-author, Dr Artur Wnorowski of the Department of Biopharmaceuticals at the School of Pharmacy at the Medical University of Lublin, Poland, conducted an interesting challenge that produced surprising results "I analyzed the main database to identify chemicals that lower the expression of the AhR and IDO1 or AhR genes I selected 596 molecules and identified a single molecule that repeatedly reduced the expression of the AhR and IDO1 or AhR genes in human cells through an in-depth analysis of 23,526 experiments involving them "
these molecules are decesemin and ostrodite glycol serorhaging of the AhR and IDO1 genes, which are active forms of vitamin D and are also thought to inhibit the spread of other viral infections Similarly, a form of vitamin E, propyating phenol, may reduce IDO1 and play an active role in dealing with viral infections and inflammation in the aging process The authors call for epidemiological studies and prospective trials to determine whether osteolycol and prophylactophenol supplements should be recommended for the prevention of SARS-CoV-2 infection " our concept is based on 40 years of research experience in tryptophan metabolism Activation of IDO1 in immune cells leads to the release of canine (a tryptophan metabolite) and activates AhR IDO1 is a clue to our recognition of the AhR-IDO1 axis concept, revealing the possible role AhR may play in COVID-19 pathogenesis," said Dr Waldemar Turski Bernhard Sabel, editor-in-chief of the Restorative And Neuroscience and a professor at the University of Magdeburg, said: "The concept of a turning point in the author's definition needs to comment on our habits, our relationship to the environment, and the AhR modulation of our education and research We seem to be at the beginning of a new path of discovery, seeing only the tip of an iceberg of unknown sizethat that could seriously affect our future "
because the authors only reported changes in gene expression, their hypothesis needed to be tested before claiming that any treatment would be beneficial to SARS-CoV-2 infection Randomized controlled trials and large-scale observational studies are also required (BioValleyBioon.com) References: How up of a single gene by SARS-CoV-2 can result in a cytokine storm Waldemar A Turski et al.
AhR and IDO1 in the couris of Covid-19 and the "Systemic AhR Activation Syndrome" translational review and therapeutic visions , restorative yn y swyddi on-the-and neuroscience (2020) DOI: 10.3233/RNN-201042