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How does the malaria parasite protect itself from fever

 Last Update: 2021-08-28
 Source: Internet
 Author: User

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journal applied microbiology

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Plasmodium falciparum is one of the most serious forms of malaria infection in humans.

"In most eukaryotes, from yeast to mammals, the expression of these proteins depends on a highly conserved transcription factor HSF1," explained Alfred Cortés, researcher and research coordinator at ISGlobal ICREA

In this study, Cortés and his team set out to investigate how the malaria parasite regulates the response to high temperature (or heat shock) in the absence of HSF1

The study’s first author Elisabeth Tintó-Font said: “This means that in addition to its role in protecting the heat shock response, PfAP2-HS is also important for maintaining the protein stability of the parasite at basal temperature

The research team found homologs of PfAP2-HS in all the Plasmodium species analyzed, even in those Plasmodiums that infect mice and do not cause fever

Journal Reference :

Elisabet Tintó-Font, Lucas Michel-Todó, Timothy J.

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