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| How does the broccoli eaten in the stomach turn into anti-cancer molecules? |
Epidemiological investigations have shown that regular consumption of cruciferous vegetables such as broccoli, cabbage, and cauliflower can prevent cancer to a certain extent.
This may be because the vegetables in this family contain indole-3-carbinol (I3C)
Recently, the Tan Renxiang team of Nanjing University published a research paper in the National Science Review (NSR).
They proposed, designed, and verified the concept of "reactive rheology" in organisms, and established methods based on this to interpret gastric acid The specific steps and determinants of the transformation of I3C into two anti-tumor molecules (DIM and LTr1) by intestinal bacteria and the mechanism by which mammals synthesize endogenous I3C and DIM
.
Among these two anti-cancer molecules, DIM is the main component of a series of marketed health products, and it is also a new anti-cancer drug candidate that has entered clinical trials
.
Unexpectedly, the anti-cancer effects of LTr1 on multiple tumor cell lines and mouse models all exceed DIM
In summary, this work found that LTr1 may have medicinal value; proposed and verified the concept of reactive rheology in organisms; established relevant experimental methods, thereby revealing the endogenous synthesis pathways and gastrointestinal pathways of I3C family molecules The Tao transformation process has given people a new understanding of the importance of cruciferous vegetables (rich in I3C)
.
(Source: Science Net)
Related paper information: https://doi.
https://doi.
org/10.
1093/nsr/nwab144
