How does carcinogenic protein "cause trouble"?
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Last Update: 2015-08-05
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Source: Internet
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Author: User
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Researchers at Kyoto University have figured out how a cancer causing protein works, which could help develop new drugs for a variety of cancers, according to a statement released recently Up to 90% of pancreatic cancer and about 40% of colorectal cancer are caused by a protein called RAS, and leukemia and lung cancer are also related to it When the protein is mutated and activated, it will promote abnormal cell proliferation and eventually lead to cancer Drugs that directly target Ras proteins will attack other similar proteins in the body at the same time, resulting in too strong side effects to be applied in practice The researchers found that to be activated, the Ras protein had to be sheared by another protein, rce1, or its role in causing cancer would be curbed Using the newly developed technology, researchers have successfully clarified the three-dimensional structure of rce1, and found that there are specific depressions on its molecule, which can pull Ras protein to shear The researchers believe that using compounds that preferentially bind to this depressed site can prevent Ras protein from being processed and activated, and prevent it from causing cancer cell proliferation Finding such compounds will help develop new drugs that can treat a variety of cancers (Xinhua)
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