How can I prevent coronaviruses from invading host cells?

New Year's Day - How to prevent new coronaviruses from entering host cells to prevent infection? A group of biomedical scientists has found a solutionScientists led by the University of California, Riverside School of Medicine report in the journal that enzymes located on the surface of host cells that handle virus invasions can be suppressed by two protease-decomposing proteinsThis protease inhibition prevents the immediate coronavirus from invading the host cellThe outer surface of the stinging glycoprotein coronavirus contains an important protein called plysin or glycoproteinGlycoproteins responsible for giving the typical canopy shape of the coronavirus are essential for viral particles to enter host cellsHowever, host cell protease must first process or cut off the surface protein of the virus to allow the virus to enter the cellPHOTO SOURCE: Laboratories and other researchers have realized that new coronaviruses, in addition to a previously discovered protease called protease, can also be processed by another human protease called Flynn Protease to enter the virus"The use of host protease Flynn protease is a common mechanism for viral fusion proteins and certain bacterial toxins to enter cells," said the biomedical professor who led the teamThis mechanism is also usedIts glycoprotein hydrolysis properties can determine whether the virus can spread across species, for example from bats or camels to humans"Fusion proteins combine the properties of more than one proteinProtein hydrolysis refers to the process of the rupture of peptide bonds between amino acids in proteins, which leads to the cutting of proteinsThe coronavirus glycoprotein contains three cleavage sites for human host protease treatmentThe exact properties and sequences of these lysate sites and their respective treatment proteases can determine the pathogenicity level of the virus and whether it can cross speciesIt was explained that similar anthrax toxins needto be treated by human flynn proteases to infect a type of white blood cell in macrophagesHis team modeled anthrax toxins on cell and animal models and found an inhibitor that effectively inhibits toxins from entering cellsA recent clinical trial for patients began using the inhibitor carmoxa "However, we found that Carmos was a very poor Flinderse inhibitor, " he said "So our current study calls for the development of more protease inhibitors or inhibitor cocktails that can simultaneously target and Flynn protease inhibition into host cells Adding that the Flynn protease cut sites that have appeared so far have been associated with increased pathogenicity But the gene elimination of Flynn Protease in cell lab studies failed to prevent the virus from entering, which suggests that it is still the most relevant protease FILE PHOTO Source: However, his team has now demonstrated that new mutations in this coronavirus strain have led to a more efficient and faster process of handling The Flynn proteases and virus invasion "In other words, unlike other less pathogenic strains, it can use protease and Flynn protease more effectively to initiate the invasion of host cells," the statement said "Although more abundant in the lungs, Flynn protease is also expressed in other organs, which may explain why it can invade and destroy multiple organs "The laboratory has identified strong and effective preclinical inhibitors of Flynn protease and demonstrated that these inhibitors can be developed as potential therapeutic drugs and may be used in combination with drugs such as the inhibitor carmoxa "We are looking for additional funding to design and develop dual inhibitors that target both Flynn protease," said The Seeking Funding This funding will enable us to explore new possible effective treatments for confrontation and support research into the potentially far-reaching applications of these studies to avoid future pandemics that could be caused by similar activation mutations in other strains of the virus () References: