[hot spot] emergency!! The hot drug oseltamivir is out of stock due to influenza (with three official influenza prescriptions)

This winter solstice is relatively wet and warm, and something is expected to happen Although influenza has gradually started in November 2017, it can be said that there is a big outbreak after the winter solstice According to the monitoring of China CDC, the number of influenza outbreaks in China has been significantly higher than that in the same period of previous years, most of which are caused by influenza B The number of children's hospitals around the world has reached a peak, and the actual number of visits has reached an amazing data According to the news, it takes 8-9 hours for a hospital in Hangzhou to queue up for paediatric visits, 9277 times for outpatient and emergency visits in Shanghai Children's Hospital, and the queuing time is up to 7 hours! It is reported that since Hong Kong entered the influenza period, the level of influenza activity has remained at a high level, and the overall death toll has caught up with the level of SARS outbreak in Hong Kong in 2003 This year's epidemic of this virus is particularly fierce, mainly influenza B although influenza A also appears in some areas, in recent times, influenza B has taken the "upper hand" Recently, the Shanghai CDC announced the resurgence of influenza B (as shown in Figure 1) Figure 1 according to the latest information of the World Health Organization, about 5-10% of adults and 20-30% of children in the world suffer from influenza every year, resulting in 3-5 million severe cases and 290-650000 deaths For the prevention and treatment of influenza, the first thing is vaccination The World Health Organization recommends that senior citizens, children, pregnant women, patients with chronic diseases and medical staff and other high-risk groups should be given priority to vaccination every year At the time of the outbreak of influenza, China CDC pointed out that neuraminidase inhibitors such as oseltamivir are effective drugs for the treatment of influenza In the early stage, especially within 48 hours after the onset of influenza, the use of anti influenza drugs can significantly reduce the incidence of severe influenza and death So far, oseltamivir has become a popular drug for the treatment of influenza in 2017 According to the pharmaceutical intelligence data, there are two dosage forms of oseltamivir in the market: capsule (75mg) and granule (15mg and 25mg) The main manufacturers are Yichang dongyangguang Changjiang Pharmaceutical Co., Ltd and Shanghai Zhongxi 3D Pharmaceutical Co., Ltd (as shown in Figure 2) The main import manufacturers are Roche Figure 2 at present, 65 oseltamivir drugs (calculated by acceptance number) have been accepted by the drug examination center, of which 7 have been approved for production (as shown in Figure 3), and 3.1 new oseltamivir phosphate APIs of Shanghai Pharmaceutical (Group) Co., Ltd Hualian pharmaceutical factory, Shanghai Sanwei Pharmaceutical Co., Ltd and Yichang Changjiang Pharmaceutical Co., Ltd have been approved for production The production of oseltamivir phosphate granules, a new chemical drug of Yichang Changjiang Pharmaceutical Co., Ltd., has also been approved There are 11 new drug applications for oseltamivir, among which 5 new chemical drugs, oseltamivir phosphate orally disintegrating tablets, from Institute of toxicants and drugs, Chinese Academy of Military Medical Sciences, have been approved for clinical use It is not difficult to see from the overall situation that there are only 5 companies with the drug layout, and only 3 companies (including imports) with the ability to produce products, with a large gap Figure 3: different specifications of oseltamivir have won the bid in 30 regions in China, and this drug has also been listed in the 2017 national medical insurance catalog, with a price of civilians and good effect, so it is used in a large amount But according to media reports, at present, many drugstores and even hospitals across the country are out of stock Previously, drug intelligence database included some agents hoping to help people in urgent need of drugs (as shown in Figure 4) in addition, in the case of drug shortage and fierce influenza, all local relevant agencies have taken preventive measures The following are the prescriptions for influenza prevention in Shandong, Shaanxi and Beijing, hoping to help the general public Attachment: