Hot search on assisted reproduction!

On September 15, the topic of “surging demand for assisted reproductive technology” appeared on Weibo's hot search
.

According to a CCTV financial report, under the encouragement of the three-child open policy, the assisted reproductive departments of many hospitals are ushering in more and more patients for consultation, and some third-class hospitals are even "difficult to find the number one

Infertility rate increased to 18%, assisted reproductive market will expand

Infertility rate increased to 18%, assisted reproductive market will expand

On May 31 this year, China's population policy ushered in a major adjustment.
The central government set the tone to fully liberalize and encourage three births
.

After China officially liberalized the "three-child" birth policy, people are most concerned about the two major issues, one is fertility and parenting costs, and the other is the issue of fertility

How to make this part of the families who are willing to give birth but are troubled by infertility to give birth to newborns smoothly? Clinically, assisted reproductive technology (Assisted Reproductive Technology, ART), drug therapy and surgical treatment are usually used
.

Assisted reproductive technology (ART) refers to the use of medical technology and methods to artificially manipulate gametes (sperm and egg), zygotes (fertilized eggs), and embryos to achieve the purpose of conception

The distribution of domestic infertility treatment methods, the picture is from the Eggshell Research Institute

Three-generation test-tube baby technology holds the gate of "prenatal and postnatal care"

Three-generation test-tube baby technology holds the gate of "prenatal and postnatal care"

ART includes artificial insemination (AI) and in vitro fertilization-embryo transfer (IVF-ET) and its derivative technologies
.

IVF-ET, also known as "test tube baby", is the dominant force in the ART market.

With the continuous advancement of technology, "test-tube babies" have experienced the iterative development of the first, second, and third generations, and the problems they solve have ranged from female infertility and male infertility to prenatal and postnatal care
.

Among them, the third-generation IVF technology is expected to become the hottest track in the field of assisted reproduction under the favorable three-child policy

The third-generation test-tube baby technology (PGT) is also called preimplantation genetic testing technology, which refers to the genetic testing and the number of chromosomes that are carried out after the sperm and egg are combined in vitro to form a fertilized egg and develop into an embryo before implantation into the mother’s uterus And the detection of structural abnormalities
.

This method can directly screen and eliminate problematic embryos, and select embryos with normal genetic material to implant in the uterus, thereby increasing the pregnancy rate, reducing the miscarriage rate, and preventing the birth of children with monogenic diseases and chromosomal abnormalities

Image courtesy of Frost & Sullivan Report

At present, the incidence of birth defects in China is about 5.
6%, and there are about 1 million new birth defects every year, of which about 250,000 are clinically obvious at birth
.

It is worth paying special attention to the older pregnant women over the age of 35, the birth defect rate of their children is more than 10 times higher than that of young pregnant women

In response to the problem of birth defects, China has been implementing three-level preventive measures, including pre-pregnancy (primary prevention), prenatal (secondary prevention) and neonatal period (tertiary prevention)
.

The "third-generation test tube baby technology" is the most important primary preventive measure for embryo screening and diagnosis, which can cut off the transmission of defective genes from the source of life

300 billion market gap

Domestic assisted reproductive medical devices ushered in an outbreak

According to Frost & Sullivan data, the penetration rate of assisted reproduction in China in 2018 was only 7.
0%, far lower than the penetration rate of 30.
2% in the United States during the same period
.
From the perspective of segmentation, the penetration rate of China's PGT is still low, only 0.
8% in 2015 and 3.
8% in 2019, while the penetration rate of the United States in 2018 has exceeded 35%
.
With the successive introduction of the three-child policy and related supporting policies, the penetration rate of assisted reproduction in China will continue to increase, and the assisted reproductive market will further expand, with huge development space and potential.
It is expected that there will be a market gap of more than 300 billion yuan.
Among them, the domestic assisted reproductive medical device market will usher in an explosion
.

IVF services mainly include ovarian stimulation, egg retrieval, egg freezing, in vitro fertilization, embryo culture, embryo screening, embryo freezing, and embryo implantation.
All services are inseparable from supporting medical equipment, such as assisted reproductive fluids, detection reagents, supplies and equipment, and other solids
.
According to the relevant regulations of the "Medical Device Classification Catalog (2018 Edition)", assisted reproductive medical devices are mainly divided into 5 categories:

Assisted reproductive catheters: embryo transfer catheters, etc.
;

Assisted reproduction puncture egg retrieval/sperm retrieval needle: egg stripping needle, egg retrieval needle, testicular puncture and sperm retrieval, epididymal puncture needle, etc.
;

Micro tools for assisted reproduction: in vitro fertilization micromanipulation tubes, culture vessels for assisted reproduction, cryopreservation tubes, etc.
;

In vitro assisted reproduction fluids: egg washing fluid, semen washing fluid, sperm gradient separation fluid, freezing fluid, thawing fluid, fertilization fluid, single sperm injection, cleavage embryo culture fluid, blastocyst culture fluid, gamete buffer, culture oil , Embryo transfer fluid, etc.
;

Assisted reproductive special equipment: a microscope microinjection, the embryo incubator, the sequencer and the like
.

Medical devices run through the whole process of assisted reproductive diagnosis and treatment, and the market demand is huge.
Domestically produced assisted reproductive medical device brands are striving to take the road of independent innovation
.
According to statistics, since 2018, more than 60 assisted reproductive medical device products have been approved in China, of which about 40 products developed by local enterprises, and the number of approvals is increasing year by year
.

While enterprises are innovating, the promulgation of a series of domestic policy documents also laid the foundation for the new development of assisted reproductive technology
.
In July this year, the "Decision of the Central Committee of the Communist Party of China and the State Council on Optimizing the Fertility Policy to Promote the Long-term Balanced Development of the Population" was formally released.
Article 12 of Chapter 4 "Improving the Level of Prenatal and Postnatal Care Services" mentions the need to promote the integration of reproductive health services into women’s health During the entire management process, Article 13 refers to strengthening prenatal screening and diagnosis, expanding the scope of neonatal disease screening, and promoting early screening, diagnosis and treatment
.
A series of favorable policies have injected a boost for capital and enterprises
.

In benchmarking developed countries, China’s assisted reproductive market has huge growth potential.
It is believed that with the emergence of innovative vitality of local enterprises and the further release of market demand under the three-child policy, China’s assisted reproductive field will achieve great progress in the next 5-10 years, and provide good health for the population.
Youyu provides strong technical support
.

Reference materials:

[1]https://new.
qq.
com/rain/a/20210427A07TJ300

[2]https://baijiahao.
baidu.
com/s?id=1698612436633334653&wfr=spider&for=pc

[3]http://